Immunohistochemical Expression of Caspase-3 in Colorectal Carcinoma | ||||
| SVU-International Journal of Medical Sciences | ||||
| Article 26, Volume 5, Issue 1, January 2022, Page 240-251 PDF (593.12 K) | ||||
| Document Type: Original research articles | ||||
| DOI: 10.21608/svuijm.2022.108052.1246 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Sheren FM Ahmed1; Christeen NB Bernaba  2; Eman M.S. Muhammad1
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| 1Department of Pathology, Faculty of Medicine, Sohag University, Sohag, Egypt. | ||||
| 2Department of Pathology, Oncology Sohag Center, Sohag ,Egypt | ||||
| Abstract | ||||
| Background: Apoptosis is an important factor in the development of tumors especially colorectal carcinomas (CRC). Caspase-3 is considered an ideal marker for measuring apoptosis in these tumors. Objectives: To evaluate the Caspase-3 expression and its correlation with the available clinicopathological criteria in patients with CRC. Patients and methods: Fifty cases of CRC removed by colectomy were enrolled in this study. Caspase-3 expression was evaluated by immunohistochemistry (IHC) using streptavidin-biotin-technique. Results: Caspase-3 appeared as brownish nuclear staining and was expressed in all cases of CRCs. Caspase-3 showed positive significant correlation with age (p= 0.046), histological variant (p= 0.02),and negative correlation with tumor grade (p < 0.001), depth of tumor invasion; T stage (p < 0.001) and lymph node status(p < 0.001). Conclusion: High expression of Caspase-3 in CRC patients related to favorable clinicopathological features and could be a potential independent prognostic factor. Caspase-3 may act as a tumor suppressor in CRC. | ||||
| Keywords | ||||
| Colorectal carcinoma; apoptosis; immunohistochemistry; Caspase-3 | ||||
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