Protective effect of Date Palm Fruits (Phoenix Dactylifera L.) versus vitamin C against mobile Phone Radiation-induced Pituitary gland damage in rats
Mohamed, R., Abdul Rahman, M., Ali, S., Ahmed, H. (2022). Protective effect of Date Palm Fruits (Phoenix Dactylifera L.) versus vitamin C against mobile Phone Radiation-induced Pituitary gland damage in rats. EKB Journal Management System, 28(3), 605-611. doi: 10.21608/zumj.2022.98393.2364
Rasha Mohamed; Maha Abdul Rahman; Sahar Ali; Heba Ahmed. "Protective effect of Date Palm Fruits (Phoenix Dactylifera L.) versus vitamin C against mobile Phone Radiation-induced Pituitary gland damage in rats". EKB Journal Management System, 28, 3, 2022, 605-611. doi: 10.21608/zumj.2022.98393.2364
Mohamed, R., Abdul Rahman, M., Ali, S., Ahmed, H. (2022). 'Protective effect of Date Palm Fruits (Phoenix Dactylifera L.) versus vitamin C against mobile Phone Radiation-induced Pituitary gland damage in rats', EKB Journal Management System, 28(3), pp. 605-611. doi: 10.21608/zumj.2022.98393.2364
Mohamed, R., Abdul Rahman, M., Ali, S., Ahmed, H. Protective effect of Date Palm Fruits (Phoenix Dactylifera L.) versus vitamin C against mobile Phone Radiation-induced Pituitary gland damage in rats. EKB Journal Management System, 2022; 28(3): 605-611. doi: 10.21608/zumj.2022.98393.2364

Protective effect of Date Palm Fruits (Phoenix Dactylifera L.) versus vitamin C against mobile Phone Radiation-induced Pituitary gland damage in rats

Zagazig University Medical Journal
Article 27, Volume 28, Issue 3, May 2022, Page 605-611  XML PDF (519.45 K)
Document Type: Original Article
DOI: 10.21608/zumj.2022.98393.2364
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Authors
Rasha Mohamed email orcid 1; Maha Abdul Rahman2; Sahar Ali3; Heba Ahmed4
1Clinical Pharmacology Department, Faculty of Medicine, Zagazig University, Zagazig,
2Department of Human Anatomy and Embryology, Faculty of Medicine, Zagazig University, Egypt
3Clinical Pharmacology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
4Clinical Pharmacology Department, Faculty of Medicine, Zagazig, University, Zagazig
Abstract
Background: Date palm fruit is one of the most precious nutraceutical compounds. Now, it is well established that mobile phone radiation causes deleterious health hazards. Pituitary gland is the master gland in the human body and is highly affected by mobile phone radiation as it’s the nearest part of the body to mobile phones during calls. This study was designed to investigate the cytoprotective effect of date palm fruit against the mobile phone radiation induced pituitary gland damage compared to vitamin C. Methods: Male Wister albino rats were exposed to mobile phone electromagnetic radiations (EMR) for 1 hour per day for 4 weeks. Rats were divided into 4 groups: control normal, EMR, EMR+ vitamin C (100 mg/kg) and EMR+ date palm fruit groups. Pituitary oxidative stress markers (malondialdehyde, MDA, and superoxide dismutase, SOD), DNA damage (8-hydroxy-2’deoxyguanosine, 8-OHdG) and apoptosis (caspase 3) were assessed. Results: Mobile phone radiation significantly increased pituitary gland oxidative stress, DNA damage and apoptosis while both vitamin C and date palm fruit significantly alleviated these detrimental effects with superior cytoprotective effect for date palm fruit over vitamin C. Conclusion: These results can introduce date palm fruit as an affordable nutraceutical agent owing to its antioxidant and antiapoptotic properties.
Keywords
Date Palm Fruits; mobile (cell) Phone Radiation; Pituitary gland; caspase; oxidative stress
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