Epidemiological Study and Clinical Characteristics of Crohn's Disease in The West Algerian Population | ||||
| Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology | ||||
| Article 5, Volume 14, Issue 1, June 2022, Page 47-54 PDF (587.91 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/eajbsc.2022.213965 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Benaissa Zahira1; Noria Harir1; Habbar Aicha2; Ouali Siheme1; Sellam Feriel2; El Mehadji Douniazad1; Belhandouz Lahcen3; Elaib Mustapha4; Kanoun Khedoudja5 | ||||
| 1Laboratory of Molecular Microbiology Health and Proteomics, Biology Department, Faculty of Natural Sciences and Life, Djillali Liabés University of Sidi-Bel-Abbés, BP No. 89 Sidi-Bel-Abbés 22000 Algeria. | ||||
| 2National Research Center of Biotechnology. RCBt | ||||
| 3Department of digestive and laparoscopic surgery, UHC Sidi-Bel-Abbés, Algeria | ||||
| 4Department of digestive and laparoscopic surgery, EHC Oran, Algeria | ||||
| 5Laboratory of Molecular Microbiology Health and Proteomics, Biology Department, Faculty of Natural Sciences and Life, Djillali Liabés University of Sidi-Bel-Abbés, BP No. 89 Sidi-Bel-Abbés 22000 Algeria | ||||
| Abstract | ||||
| Background: Crohn's disease (CD) is a chronic multifactorial inflammatory disorder, characterized by discontinuous lesions that affect the entire gastrointestinal tract from the mouth to the anus. The aim of our work was focused more particularly on the study and determination of epidemiological data, clinical, para-clinical and therapeutic aspects of Crohn's disease in the Western Algerian population. Methods: A retrospective analytical study was carried out at the level of the general surgery department (western Algeria), during the period 2008-2019. Results: During the period of our study, which ran from 2008-2019, we collected 300 cases of Crohn's disease. 184 males and 116 females with a sex ratio of 1.6. Anemia, ESR and CRP were the most impaired biological noted signs. The ileo-caecal location was the most dominant (56%) and the most common phenotype was the inflammatory type (47%). Statistical analysis showed an evidence association between Colic location, ilea-caecal location and gender ( p=0.005; p=0.017). Similarly, we noted a significant relation between Colic location, ilea-caecal location and < 40-year group (P=0.007, p=0.005 respectively). The treatment of Crohn's disease was essentially medical. Nevertheless, surgery remains necessary in most patients as 79% underwent it. Postoperative morbidity was dominated by the occurrence of recurrence (83%). As major risk factors, we noted appendectomy at 17%, smoking at 22.7% and oral contraception at 32%. Conclusions According to our results Crohn's disease is a frequent pathology, its care remains multidisciplinary despite a well-conducted medical treatment and complicated cases are frequently observed. The therapeutic sanction remains surgical which does not protect the patient from the occurrence of recurrence. | ||||
| Keywords | ||||
| Crohn disease; Epidemiology; clinical aspect; para-clinical aspect; therapeutic aspect, morbidity | ||||
|
Statistics Article View: 610 PDF Download: 794 |
||||
