Assessment of 8-Hydroxy-2-Deoxyguanosine in Vitiligo Patients

Saleh, A.A.; Hussein, M.S.; Abdelrahman, A.M.; Alzard, O.K.

doi:10.21608/bjas.2021.214421

	Assessment of 8-Hydroxy-2-Deoxyguanosine in Vitiligo Patients
Benha Journal of Applied Sciences
Article 28, Volume 6, Issue 6, December 2021, Page 231-234 PDF (574.34 K)
Document Type: Original Research Papers
DOI: 10.21608/bjas.2021.214421
View on SCiNiTO
Authors
A.A. Saleh¹; M.S. Hussein¹; A.M. Abdelrahman²; O.K. Alzard¹
¹Dermatology, Andrology & Venereology, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
²Clinical and Chemical Pathology, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
Abstract
Background: Acquired pigmentary condition, vitiligo, has an unclear aetiology and is likely multi-factorial, involving hereditary factors and defective metabolic pathways as well as immunological processes, melanocyte adhesion defects, and nervous system abnormalities. White macules appear on the skin as a result of the selective loss of melanocytes in the affected area. More than 2% of the world's population is infected, and it shows no preference for gender or ethnicity. Treatment results in varying degrees of improvement or worsening of symptoms. Psychological discomfort, a lowered standard of living, and an elevated risk of mental illness are all possible side effects of depigmentation. Excess levels of the oxidative stress biomarker 8-hydroxy-2-deoxyguanosine in bodily fluids are an excellent predictor of oxidative stress-related disease. In this research, 8-hydroxy-2-deoxyguanosine levels in vitiligo patients and healthy controls will be measured, and the results compared. This research was conducted at Banha University Hospital's Dermatology, Andrology, and Medical Biochemistry departments. From October 2020 to February 2021, 60 vitiligo patients were recruited from Banha University Hospital's outpatient clinic of Dermatology, Venereology. Results: The blood level of 8-OHdG was found to be substantially greater in patients than in the control group in this investigation (P 0.001). 8-OHdG, on the other hand, exhibited a reasonable degree of diagnostic accuracy for vitiligo. It has a sensitivity of 96.67 percent and a specificity of 76.67 percent for diagnosing vitiligo at cutoff values over 5 ng/ml. Serum 8-OHdG levels were shown to be significantly correlated with patient age (P 0.001), illness duration (P 0.001), and VETI score (P = 0.063) in the research. Patients with vitiligo had greater amounts of 8-OHdG than healthy individuals, according to the findings of this research. 8-OHdG levels are linked to vitilgo VETI scores, family history, and the length of the illness. 8-OHdG levels may suggest that oxidative unit is a major role in the development of vitiligo, as shown by these findings. Patients with vitiligo may benefit from the findings of this research, which might point the way toward new treatment options.
Keywords
8-Hydroxy-2; Deoxyguanosine; Vitiligo


Statistics Article View: 121 PDF Download: 312