Snake Venoms-Based Compounds as Potential Anticancer Prodrug: Sand Viper Cerastes Cerastes as a Model | ||||
| Egyptian Journal of Chemistry | ||||
| Article 6, Volume 65, Issue 8, August 2022, Page 43-55 PDF (324.23 K) | ||||
| Document Type: Review Articles | ||||
| DOI: 10.21608/ejchem.2022.97479.4631 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Maryham Aziz  1; Mohamed Ahmed Abdel-Rahman 2; Osama Abbas3; Eman Abdel-Moemen Mohamed4; Mohamed Hassan3
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| 1Zoology department, faculty of Science, Port Said university, Port Said, Egypt. | ||||
| 2Professor of Molecular Toxicology & Physiology of zoology, Zoology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt. | ||||
| 3Zoology department, Faculty of Science, Port Said university, Port Said, Egypt | ||||
| 4Genetics Unit, Histology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. | ||||
| Abstract | ||||
| Cancer is a major public health problem, recently known as the disease of the millennium. Proliferation of tumor cells, angiogenesis and the relationship between cancer cells and extracellular matrix components are important events in carcinogenesis. Many of these pathways are being used as targets for new anticancer therapeutic approaches. Various venoms and their toxins have shown possible anticancer effects on human cancer cell lines, providing new perspectives for drug development. For instance, snake venoms is a complex mixture of different proteins, peptides, enzymes, carbohydrates and other bioactive molecules that are either secreted by the snake in predation or protection against threats. Snake venoms are largely cytotoxic to the malignant cells compared to the normal one. Therefore; venoms, have a number of therapeutic actions which make them an attractive approach for cancer therapy. In this review, we shed light onto the importance of the venom isolated from a desert-horned or Egyptian sand viper Cerastes cerastes as a potential therapeutic drug | ||||
| Keywords | ||||
| Cancer; Anticancer therapy; Carcinogenesis; Snake venom; Egyptian sand viper, Cerastes cerastes; toxins | ||||
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