Propofol versus combined propofol &Dexmedetomidine for conscious sedation in colonoscopy | ||||
| Azhar International Journal of Pharmaceutical and Medical Sciences | ||||
| Article 12, Volume 2, Issue 1, January 2022, Page 117-123 PDF (317.63 K) | ||||
| Document Type: Original research articles | ||||
| DOI: 10.21608/aijpms.2022.107855.1098 | ||||
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| Authors | ||||
Amira Fahim Lashin  1; Gehan Abdelrahman Eldesoky1; Alshaimaa M.M. Eid2; Sammar Ahmed Kasim3
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| 1Department of Anesthesiology and Intensive Care, Faculty of Medicine, Al-Azhar University. Cairo, Egypt. | ||||
| 2Department of Hepatology, Gastroenterology and Infectious Diseases, Faculty of Medicine, Al-Azhar University, Cairo, Egypt. | ||||
| 3Department of Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt. | ||||
| Abstract | ||||
| Colonoscopy is an endoscopic procedure that examines the mucosa of the large intestine and distal terminal ileum for histopathological sampling and therapeutic procedures. Methods: Forty patients of both sexes candidates for colonoscopy were randomized to (D group & P group) each one included 20 patients: D Group: Dexmedetomidine was given as an initial loading dosage of 1 µg/kg i.v over ten minutes then received propofol 0.5mg/kg, then a continuous I.V. dexmedetomidine infusion (0.2–0.8) µg/kg/h was started until the procedure completed. P Group: The intravenous loading dose of propofol 2 mg/kg was given, then a continuous infusion of propofol 25–100 µg/kg/min was started until the procedure was completed. Results: The level of sedation was assessed using the Ramsay Sedation Score (RSS) showed a significant increase in the P group (2-2) compared to the D group activity (1-2) throughout 1-hour post-operatively. After 5 min of the procedure heart rate significantly decreased in group D then it became non-significant during the remaining time. The oxygen saturation % values showed a significant reduction in the P group (mean 95.45 ± 2.70) at 5 min of the procedure then it became non-significant during all remaining time. Although Bradycardia was more significantly higher in the D group, hypotension and respiratory complications were more significant higher in the P group. Also, the endoscopist was satisfied in the D group. Conclusion: In patients undergoing colonoscopy, dexmedetomidine combined with a low dose of propofol resulted in greater conscious sedation and adequate endoscopist satisfaction than propofol alone. | ||||
| Keywords | ||||
| dexmedetomidine; propofol; conscious; sedation; colonoscope | ||||
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