One- Pot Synthesis of New Pyranopyrazoles Via Domino Multicomponent Reaction | ||||
| Egyptian Journal of Chemistry | ||||
| Article 24, Volume 65, Issue 10, October 2022, Page 259-265 PDF (1.09 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2022.115337.5232 | ||||
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| Authors | ||||
Shaymaa Khazaal   1; Shaimaa Y. Ibraheam 2
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| 1Dept. of Chemistry, College of Science, Mosul University. | ||||
| 2Deprt. of chemistry- College of Science-University of mosu | ||||
| Abstract | ||||
| An active heterocyclic unite building represented by 1,3,4-Thiadiazole-2,5-dithiole (1) was prepared through the reaction of carbon disulfide and hydrazine hydrate .This unite building was reacted with hydrazine hydrate to afford the corresponding 2,5-dihydrazino -1,3,4-thiadiazole(2)which then undergoes one-pot catalyst-free multicomponent reaction with malononitrile, substituted aldehyde and ethyl acetoacetate to obtained 2,5-di(3-methyl-4-aryl-pyrano[2,3-c]pyrazole-5-amino-6-cyno-1-yl)-1,3,4-thiadiazole (3-9). All prepared compounds were elucidated by available methods represented by M.P,T.L.C,FT-IR and for some compounds 1H.NMR. | ||||
| Keywords | ||||
| multicomponent reaction; pyrano 2; 3-cpyrazole 1; 3; 4-thiadiazole; pyrazole; green chemistry | ||||
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