Preconception H pylori infection might be a risk factor for Development of Early-onset Preeclampsia
Mohammed Marei, A. (2022). Preconception H pylori infection might be a risk factor for Development of Early-onset Preeclampsia. EKB Journal Management System, 26(1), 2-11. doi: 10.21608/egyfs.2022.216260
Amr Sharaf Elden, Yasmin Mohammed Marei. "Preconception H pylori infection might be a risk factor for Development of Early-onset Preeclampsia". EKB Journal Management System, 26, 1, 2022, 2-11. doi: 10.21608/egyfs.2022.216260
Mohammed Marei, A. (2022). 'Preconception H pylori infection might be a risk factor for Development of Early-onset Preeclampsia', EKB Journal Management System, 26(1), pp. 2-11. doi: 10.21608/egyfs.2022.216260
Mohammed Marei, A. Preconception H pylori infection might be a risk factor for Development of Early-onset Preeclampsia. EKB Journal Management System, 2022; 26(1): 2-11. doi: 10.21608/egyfs.2022.216260

Preconception H pylori infection might be a risk factor for Development of Early-onset Preeclampsia

The Egyptian Journal of Fertility of Sterility
Article 1, Volume 26, Issue 1 - Serial Number 11106352, January 2022, Page 2-11  XML PDF (2.51 MB)
Document Type: Original Article
DOI: 10.21608/egyfs.2022.216260
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Author
Amr Sharaf Elden, Yasmin Mohammed Marei1, 2
1Department of Obstetrics & Gynecology, Faculty of Medicine, Benha University
2Department of Medical Biochemistry, Faculty of Medicine, Benha University
Abstract
Objectives: Estimation of serum levels of Tumor necrosis factor-α (TNF-α), interleukin-1β and -6 at booking time
and at time of diagnosis of preeclampsia (PE) in women
infected and un-infected by H pylori (HP).
Patients & Methods: 232 primigravida gave blood samples for ELISA determination of HP IgG positivity and
were categorized as HP+ and HP- groups. At booking
time, systolic (SBP) and diastolic (DBP) blood pressure
measures were recorded and serum levels of TNF-α, IL-1β
and IL-6 were ELISA estimated (S1 sample). During the
4-weekly visit, BP was recorded to diagnose PE according
to the American Society of Hypertension. At time of PE
diagnosis, S2 blood sample was obtained for re-estimation
of studied cytokines.
Results: There were 108 HP+ women and 54 women developed PE; 33 HP+ and 21 HP- women. The incidence of early-onset PE was significantly higher, while the incidence of
severe PE was non-significantly higher among HP+ women.
Positivity for HP IgG showed positive significant correlation with development of early and severe PE. At booking
serum levels of studied cytokines were significantly higher in PE than Non-PE women and in HP+ women than in
HP- women and showed positive significant correlation with
BP measures at time of diagnosis of PE. Automatic Linear
Modeling analysis defined high at booking serum TNF-α as
the most important predictor for PE.
Conclusion: PE has a higher incidence among women
had HP infection, which might be considered as precipitating factor for PE development. The positive correlation
between severity of PE, HP-IgG positivity and increased
serum levels of inflammatory cytokines represent a dangerous circle entrapping the pregnant women.
Keywords
H pylori infection; Preeclampsia; Primigravida; Inflammatory cytokines
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