Intrauterine infusion of autologous Platelet-rich plasma before frozen embryo transfer in patients with prior implantation failure: A randomized controlled study | ||||
| The Egyptian Journal of Fertility of Sterility | ||||
| Article 2, Volume 26, Issue 1 - Serial Number 11106352, January 2022, Page 12-22 PDF (2.53 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/egyfs.2022.216262 | ||||
 View on SCiNiTO | ||||
| Author | ||||
Ayman Shehata Dawood
| ||||
| Department of obstetrics and gynecology, Tanta University, Tanta, Egypt | ||||
| Abstract | ||||
| Objectives: To evaluate whether intrauterine infusion of autologous platelet rich plasma (PRP) in patients with prior implantation failure (RIF) improves pregnancy rate or not. Materials and methods: This randomized controlled study was conducted at 4 fertility centers in the period from December 1, 2018 to October, 2021. Patients with repeated implantation failure were recruited and randomly allocated into either study group who received PRP intrauterine infusion or control group who received intrauterine saline infusion. The primary outcome was occurrence of pregnancy. Secondary outcome was increase in endometrial thickness. Results: Basal demographic data of enrolled patients were comparable. The endometrial thickness on the 11th day did not differ between control and treatment group, 8.5± 1.34mm and 8.18± 1.35mm respectively, P=0.23, while the thickness was significantly increased in the study group at FET P=0.04. Clinical pregnancy rate was 10.92% in the control group versus 16.81% in the study group (P= 0.22). Implantation rate was 15.97% in the control group versus 21.24% in the study group (P= 0.36). Endometrial thickness at FET was correlated to high pregnancy rate. Conclusion: Although PRP infusion increased endometrial thickness and pregnancy rates in the treatment and control group, but the difference didn't reach to clinical significance. | ||||
| Keywords | ||||
| Repeated implantation failure; PRP; Frozen embryo transfer; implantation rate; Clinical pregnancy rate | ||||
|
Statistics Article View: 178 PDF Download: 267 |
||||
