Evaluation of Addition Of Sildenafil Citrate On Fetal Growth And Doppler Indices In Treatment of Pregnancy Induced Hypertension | ||||
Egyptian Journal of Medical Research | ||||
Article 6, Volume 3, Issue 1, January 2022, Page 68-83 PDF (482.58 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejmr.2022.216583 | ||||
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Authors | ||||
Eman Zein Elabdein Farid; Hamada Ashry Abdel-wahed; Heba Abdel-Aleem Hemida | ||||
Obstetrics and Gynecology department, Faculty of Medicine, Beni-Suef University, Egypt | ||||
Abstract | ||||
Pregnancy induced hypertension (PIH) is the most common complication during pregnancy and it affects up to 12% of pregnancies. It is the leading cause of maternal and fetal morbidity and mortality (1). Sildenafil is a potent and selective inhibitor of cGMP .which results in increased levels of cGMP, leading to smooth muscle relaxation thus mediating improved uteroplacental perfusion and increased fetal growth (12). Objectives:This study is to evaluate effect of sildenafil citrate on fetal growth and Doppler indices in treatment of pregnancy induced hypertension Setting:Department of Obstetrics &Gynecology, Beni-Suef University Hospital. Methods:Patients were divided into two groups: Group A (sildenafil group) were offered Sildenafil 20 mg t.i.d. with a plenty of fluids until delivery in addition to traditional treatment. Group B (Placebo group) received placebo drug with the same shape and texture as sildenafil citrate in addition to traditional treatment.Main outcome measures: Utero placental perfusion, fetal growth and maternal and fetal safety. Results: Sildenafil treatment was associated with a significant decrease of SBP between the two time points (P-value<0.001), a significant decrease of DBP between the two time points (P-value<0.001) and increase in estimated fetal weight by ultrasound (P<0.001). Conclusions: Despite limited data, overall there does not appear to be any severe adverse maternal side effects nor any increase in the rate of stillbirths, neonatal deaths attributed to SC. | ||||
Keywords | ||||
sildenafil; pregnancy induced hypertension; IUGR; Doppler indices | ||||
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