Evaluation of Biocompatibility of two bioactive composite resin materials versus MTA: A Comparative histopathological study | ||||
| Egyptian Dental Journal | ||||
| Article 1, Volume 68, Issue 1 - Serial Number 3, January 2022, Page 313-322 PDF (1.7 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/edj.2021.68986.1560 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Fawzy Darweesh   1; Mohammad Elnawawy2; Enas Anan 3; tayseer maaly 4
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| 1Assistant Professor, Oral Biology Dep. Faculty of Dentistry, Zagazig University | ||||
| 2Assistant Professor, Conservative Dentistry Dep. Faculty of Dentistry, Mansoura University | ||||
| 3Associate Professor, Department of Dental Biomaterials, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.. | ||||
| 4Assistant Professor, Dental Biomaterials Department, Faculty of Dentistry, Zagazig University | ||||
| Abstract | ||||
| Abstract Objective: This study was conducted to evaluate the biocompatibility of two bioactive materials, Cention N (CN) and ACTIVA bioactive, then compare the result with that of Mineral Trioxide Aggregate (MTA) as a retrograde filling materials. Methods: Sixty Albino male rats were used in the study, four polyethylene tubes were subcutaneously implanted into the rats, an empty one was used as a control group, and the other three tubes were filled with ACTIVA, Cention N and MTA-HP. Rats were then divided into three groups (n = 20 rats) following the sacrification time into three intervals: one, two and three weeks, then, the tissue specimens were analyzed histopathologically. The collected data were subjected to statistical analysis. Results: ANOVA test showed that the lowest inflammatory reaction was recorded for ACTIVA while a high degree of chronic inflammation was recorded for MTA group, with highly significant differences, P< 0.001. ACTIVA bioactive material exhibited observable decline of inflammation and fibrosis in a comparison to the control. Conclusions: The two bioactive materials showed a higher biocompatibility comparable to MTA. ACTIVA showed the highest degree of biocompatibility related to the decreased intensity of inflammation, with well-formed fibrous connective tissue conversion and improved healing patterns. | ||||
| Keywords | ||||
| Keywords: Biocompatibility; Bioactive; ACTIVA; Cention N | ||||
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