Steroid Responsiveness and Urinary Monocyte Chemotactic Protein-1 in Children with Nephrotic Syndrome.
Abdel Haie, O., El Hamshary, A., El Fallah, ., Mohammed, A., Afifi, W. (2021). Steroid Responsiveness and Urinary Monocyte Chemotactic Protein-1 in Children with Nephrotic Syndrome.. EKB Journal Management System, 16(2), 31-39. doi: 10.21608/geget.2021.216774
Omima Abdel Haie; Abdel Hamid El Hamshary; ِAsmaa El Fallah; Ashraf Roshdy Mohammed; Wesam Afifi. "Steroid Responsiveness and Urinary Monocyte Chemotactic Protein-1 in Children with Nephrotic Syndrome.". EKB Journal Management System, 16, 2, 2021, 31-39. doi: 10.21608/geget.2021.216774
Abdel Haie, O., El Hamshary, A., El Fallah, ., Mohammed, A., Afifi, W. (2021). 'Steroid Responsiveness and Urinary Monocyte Chemotactic Protein-1 in Children with Nephrotic Syndrome.', EKB Journal Management System, 16(2), pp. 31-39. doi: 10.21608/geget.2021.216774
Abdel Haie, O., El Hamshary, A., El Fallah, ., Mohammed, A., Afifi, W. Steroid Responsiveness and Urinary Monocyte Chemotactic Protein-1 in Children with Nephrotic Syndrome.. EKB Journal Management System, 2021; 16(2): 31-39. doi: 10.21608/geget.2021.216774

Steroid Responsiveness and Urinary Monocyte Chemotactic Protein-1 in Children with Nephrotic Syndrome.

GEGET
Article 3, Volume 16, Issue 2, December 2021, Page 31-39  XML PDF (263.11 K)
Document Type: Original Article
DOI: 10.21608/geget.2021.216774
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Authors
Omima Abdel Haie1; Abdel Hamid El Hamshary1; ِAsmaa El Fallah2; Ashraf Roshdy Mohammed email 3; Wesam Afifi4
1Department of Pediatrics, Faculty of Medicine, Benha University, Benha, Egypt.
2Department of Clinical Pathology, Faculty of Medicine, Benha University, Benha, Egypt.
3Department of Pediatrics, Samanoud Central Hospital, Gharbia, Egypt
4Pediatric department, Faculty of medicine, Benha university, Benha, Egypt.
Abstract
Introduction: Idiopathic nephrotic syndrome is a clinical syndrome marked by a significant loss of urine protein, resulting in hypoproteinemia and edema.The recruitment of monocytes/macrophages into the renal tubulointerstitium is aided by the moncyte chemotactic protein-1.
Aim of the study: The aim of our study was planned to measure the level of monocyte chemotactic protein 1 in the urine of children with idiopathic nephrotic syndrome during disease activity and remission as well as in steroid sensitive and steroid resistant cases to identify a possible predictive biomarker of disease activity and/or steroid responsiveness.
Methods: This prospective study comprised 50 patients with nephrotic syndrome who were followed up on at Pediatric Nephrology Clinic and Department, Benha University, and were divided into two groups: group A (cases in remission) and group B (cases in activity). Also, 20 age and sex matched healthy children have been included as a control group.
Results: We found a significant increase in urinary moncyte chemotactic protein-1(uMCP-1) in idiopathic nephrotic syndrome patients as compared to control group (p < 0.001). Also, the greatest levels of uMCP-1 were found in group B, followed by group A, and then the control group (p < 0.001). The steroid resistant nephrotic syndrome patients had significantly higher uMCP-1 levels than the steroid sensitive nephrotic syndrome patients (p < 0.001).
Conclusion: Urinary MCP-1 can be considered a useful biomarker for identification of disease activity in children with INS, as well as a potential predictive biomarker of steroid responsiveness among these patients.
Keywords
Nephrotic Syndrome; Relapse; Remission; Steroid Sensitive; Steroid Resistant; Urinary monocyte chemotactic protein-1
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