Proadrenomedullin in neonatal sepsis | ||||
| Minia Journal of Medical Research | ||||
| Volume 31, Issue 4, October 2020, Page 158-161 PDF (128.65 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2022.217563 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Ashraf M. Osman; Mohammed A. Abd El-Hakeem; Khadiga Hussein Soliman | ||||
| Department of Clinical Pathology, El-Minia Faculty of Medicine | ||||
| Abstract | ||||
| Neonatal sepsis continues to be a global problem with significant morbidity and mortality. The diagnosis of neonatal sepsis is complicated by nonspecific clinical symptomatology, a high-false negative rate, and a delay in obtaining blood culture results. Subjects and Methods: The prospective cohort study was conducted in the Department of Clinical pathology and Neonatal Intensive Care Unit (NICU) at Minia University hospitals during the period from August 2014 to October 2015. Neonates were classified into two groups: group I: included 60 neonates with sepsis divided into 2 subgroup, 36 EOS (subgroup Ia) and 24 LOS (subgroup Ib), 27 female, 33 male, their ages ranged from 1 day to 27 days. group II: included 30 apparently healthy neonates 8 female, 22 male their ages ranged from 1 day to 24 days who served as a control group of matched age and sex. Results: The present study included ninty neonates, sixty with sepsis (group I) in addition into thirty apparent healthy neonates who served as a control group (group II) of matched age and sex. Recommendation: Proadrenomedullin may be used as a routine investigation for early diagnosis of neonatal sepsis besides blood culture and procalcitonin. Further studies on larger population are recommended to investigate the prognostic value of proadrenomedullin. | ||||
| Keywords | ||||
| Neonatal sepsis; Proadrenomedullin | ||||
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