Dyslipidemia in Breast Cancer patients | ||||
Minia Journal of Medical Research | ||||
Volume 31, Issue 4, October 2020, Page 192-196 PDF (115.88 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/mjmr.2022.217927 | ||||
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Authors | ||||
Sahar H. El Hini1; Ahmed M. Saad El Din1; Marwa , I. Mohamed2; Asmma K. Ahmed2 | ||||
1Department of Internal Medicine, Diabetes and Endocrinology unit, Minia School of Medicine, Minia University | ||||
2Department of Internal Medicine, Diabetes and Endocrinology unit, Minia School of Medicine, Minia University. | ||||
Abstract | ||||
Background: Breast cancer (BC) is the most prevalent cancer and primary cause of cancerrelated mortality in women. The identification of risk factors can improve prevention of cancer[1] . Research on breast cancer cells have demonstrated an important role for cholesterol and its transporters in breast cancer development. Instead of cholesterol, the cholesterol metabolite 27-hydroxycholesterol induces the proliferation of estrogen receptor-positive breast cancer cells and facilitates metastasis[2]. Oxidative modification of the lipoproteins and HDL glycation activate different inflammation-related pathways, thereby enhancing cell proliferation and migration and inhibiting apoptosis[3] . Aim of the work: The study’s primary aim was to investigate the LDL, HDL and TG serum levels in patients with BC and in comparison with control subjects. In addition to evaluate different BC risk factors. Patients and Methods: The study estimated LDL, HDL and TG serum levels in 70 patients with BC and 50 healthy subject. Results: patient with breast cancer had significantly higher level of serum LDL with a mean (133.39±23.76) compared to control subjects (119.26±11.01) as p value (<0.001), HDL level was significantly low in breast cancer patients compared to control with a mean (52.74±5.9) in breast cancer patients compared to (55.88±5.34) in control subjects as p value (0.003) and Triglycerides level was significantly high in breast cancer patients compared to control with a mean (141.79±17.74) in breast cancer patients compared to (132.04±11.95) in control subjects as p value (0.001). Conclusion: Serum HDL level is significantly lower in breast cancer patients compared to control. While serum LDL and triglycerides are significantly higher. | ||||
Keywords | ||||
Breast cancer; low-density; high density lipoproteins | ||||
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