The Associations between HLA DQB1 different Alleles and β-thalassemia Major
Kamal Eldin, A., Abd El Naem, ,., Elsayed, M., Zaki Mahmoud, N. (2020). The Associations between HLA DQB1 different Alleles and β-thalassemia Major. EKB Journal Management System, 31(4), 197-200. doi: 10.21608/mjmr.2022.217932
Amel M. Kamal Eldin; ,Emad A. Abd El Naem; Mostafa A. Elsayed; Nada O. Zaki Mahmoud. "The Associations between HLA DQB1 different Alleles and β-thalassemia Major". EKB Journal Management System, 31, 4, 2020, 197-200. doi: 10.21608/mjmr.2022.217932
Kamal Eldin, A., Abd El Naem, ,., Elsayed, M., Zaki Mahmoud, N. (2020). 'The Associations between HLA DQB1 different Alleles and β-thalassemia Major', EKB Journal Management System, 31(4), pp. 197-200. doi: 10.21608/mjmr.2022.217932
Kamal Eldin, A., Abd El Naem, ,., Elsayed, M., Zaki Mahmoud, N. The Associations between HLA DQB1 different Alleles and β-thalassemia Major. EKB Journal Management System, 2020; 31(4): 197-200. doi: 10.21608/mjmr.2022.217932

The Associations between HLA DQB1 different Alleles and β-thalassemia Major

Minia Journal of Medical Research
Volume 31, Issue 4, October 2020, Page 197-200  XML PDF (214.52 K)
Document Type: Original Article
DOI: 10.21608/mjmr.2022.217932
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Authors
Amel M. Kamal Eldin; ,Emad A. Abd El Naem; Mostafa A. Elsayed; Nada O. Zaki Mahmoud
Department of Clinical Pathology, Faculty of Medicine, Minia university
Abstract

Thalassemias are the commonest inherited hemoglobinopathies in the world. Approximately 68,000 
children are born with various thalassemia syndromes each year. β-Thalassemia represents a major 
public health problem in Egypt. beta thalassemia. It is caused by reduced or absent synthesis of beta 
globin chains. Aim of the work: Determine frequencies & association of HLA DQB1 alleles in βthalassemia major patients. Patients: forty-five unrelated randomly selected β-thalassemia major 
patients, and forty-five unrelated randomly selected healthy individuals, composed the control group 
with age matched to patients of group I. Study procedure: Routine lab investigations & HLA DQB1 
genotyping by real time PCR. The Kit were supplied by DNA-TECHNOLOGY (catalog no.334-1), 
Russia. Conclusion: HLA DQB1*0601 give significance importance as an etiological risk factor for 
β-thalassemia major; HLA DQB1*0302 give significance importance as a preventive risk factor for βthalassemia major.

Keywords
beta thalassemia major; HLA class II; Real time PCR
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