Predictors of Sustained Virological Response in Chronic Hepatitis C Patients Treated with Current Direct Acting Antiviral Drugs | ||||
Minia Journal of Medical Research | ||||
Volume 31, Issue 4, October 2020, Page 204-211 PDF (190.48 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/mjmr.2022.217944 | ||||
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Authors | ||||
Elwy MK Soliman1; Hisham A Morsy,2; Ashraf M. Othman3; Ahmed M. Mady3 | ||||
1Department of Internal Medicine, , Faculty of Medicine, Minia University, Minya, Egyp | ||||
2Department of Internal Medicine, , Faculty of Medicine, Minia University, Minya, Egypt | ||||
3Department of Clinical Pathology, Faculty of Medicine, Minia University, Minya, Egypt | ||||
Abstract | ||||
Background and aims: Treatment of hepatitis C virus (HCV) changed dramatically with the introduction of oral direct-acting antiviral drugs due to their high antiviral potency and safety profile. Sofosbuvir plus daclatasvir combination therapy was extensively investigated in HCV genotypes 1, 2, and 3, while published data regarding its real-life application in the treatment of genotype 4 is lacking. Therefore, we conducted this study to assess the outcomes and predictors of treatment response with sofosbuvir plus daclatasvir with or without ribavirin in Egyptian patients with genotype 4 hepatitis C virus infection. Patients and methods: This prospective study included 200 Egyptian patients with chronic genotype 4 HCV, treated with sofosbuvir plus daclatasvir with or without ribavirin for 12 weeks. Evaluation of number of non-responders, their demographics, and evaluation of C-X-C motif chemokine- 10(CXCL-10) level, interleukin 12 (IL 12) and natural killer (NK) cell phenotype pretreatment and12 weeks of treatment. Results: A total of 92.5% of all patients achieved SVR12. SVR12 rates of 96.29% and 84.61% were reported in non-cirrhotic and cirrhotic patients, respectively. Older age, cirrhosis, low platelet count, high level of CXC-L 10 , lower NK cell frequency and lower frequency of the NK subset CD56−CD16+ were the predictors of treatment non-response. Conclusion: Based on this prospective study, sofosbuvir plus daclatasvir with or without ribavirin for 12 weeks appears to have favorable outcomes in the treatment of genotype 4 HCV-infected Egyptian patients. Older age, cirrhosis, and low platelet count, high level of CXC-L 10 , lower NK cell frequency and lower frequency of the NK subset CD56-CD16+ are independent risk factors of treatment non-response. | ||||
Keywords | ||||
hepatitis C virus; genotype 4; sofosbuvir plus daclatasvir; sustained virologic response | ||||
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