High Snail 1 Expression is a Poor Prognostic Factor in Patients with Invasive Ductal Carcinoma of the Breast | ||||
| Minia Journal of Medical Research | ||||
| Volume 31, Issue 4, October 2020, Page 287-295 PDF (620.08 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2022.218143 | ||||
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| Authors | ||||
| Mona A. Mohamed; Salwa G. Teleb; Dalia M. Abd El-Rehim; Manal I. Abd-Elghany; Mariana F. Gayyed | ||||
| Department of pathology, Faculty of Medicine, Minia University, Egypt | ||||
| Abstract | ||||
| Breast carcinoma is the most common cancer in Egyptian women. Developing metastasis is the leading cause of death in patients with invasive ductal carcinoma of the breast. The epithelial–mesenchymal transition (EMT) plays an important role in breast cancer metastasis. Snail 1 is a key regulator of the EMT of tumor cells. Aim: To study the immunohistochemical expression of Snail 1 in invasive ductal carcinoma NOS of the breast and their association with different clinicopathological features of breast IDC. Material and methods: This study comprised 70 cases of IDC-NOS of the breast. Formalin fixed and paraffin-embedded tissue sections from cases under investigation were subjected to haematoxylin and eosin staining and immunohistochemical staining for Snail 1 using the avidin biotin-peroxidase complex method. Results: Snail 1 immunostaining was nuclear. High snail 1 expression was detected in 52.86% of cases. High snail 1 expression was significantly associated with larger tumor size, higher tumor grade, higher lymph node stage, higher LNR, advanced tumor stage, poor Nottingham prognostic index (NPI), high Ki-67 PIs, high Her-2 neu expression, negative ER hormonal receptors, negative PR hormonal receptors and aggressive molecular subtypes being highest in triple negative and her-2 enriched types (P= 0.028, 0.003, 0.024, 0.002, 0.001, 0.001, 0.001, 0.011, 0.002, 0.001, 0.002 respectively). High Snail 1 expression had significantly shorter OS (p <0.001) and poor DFS (p< 0.001). Snail 1 was independent prognostic indicators for OS (P= 0.03) and DFS (p<0.001). Conclusions: High snail 1 expression is associated with poor clinicopathological features of IDC of the breast, aggressive behavior of the tumor, shorter Os and Poor DFS. | ||||
| Keywords | ||||
| Snail 1; EMT; IDC; DFS | ||||
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