CARBETOCIN VERSUS OXYTOCIN IN THE PREVENTION OF POSTPARTUM HEMORRHAGE FOLLOWING VAGINAL DELIVERY IN HIGH RISK PATIENTS
Abdel Fatah, M., Salama, K., Edris, Y., Metwally, A. (2022). CARBETOCIN VERSUS OXYTOCIN IN THE PREVENTION OF POSTPARTUM HEMORRHAGE FOLLOWING VAGINAL DELIVERY IN HIGH RISK PATIENTS. EKB Journal Management System, 39(1), 112-122. doi: 10.21608/bmfj.2022.17612.1083
Mahmoud Abdulla Abdel Fatah; khaled Mohamed Salama; Yehia Mohamed Samir Edris; Amany Mostafa Metwally. "CARBETOCIN VERSUS OXYTOCIN IN THE PREVENTION OF POSTPARTUM HEMORRHAGE FOLLOWING VAGINAL DELIVERY IN HIGH RISK PATIENTS". EKB Journal Management System, 39, 1, 2022, 112-122. doi: 10.21608/bmfj.2022.17612.1083
Abdel Fatah, M., Salama, K., Edris, Y., Metwally, A. (2022). 'CARBETOCIN VERSUS OXYTOCIN IN THE PREVENTION OF POSTPARTUM HEMORRHAGE FOLLOWING VAGINAL DELIVERY IN HIGH RISK PATIENTS', EKB Journal Management System, 39(1), pp. 112-122. doi: 10.21608/bmfj.2022.17612.1083
Abdel Fatah, M., Salama, K., Edris, Y., Metwally, A. CARBETOCIN VERSUS OXYTOCIN IN THE PREVENTION OF POSTPARTUM HEMORRHAGE FOLLOWING VAGINAL DELIVERY IN HIGH RISK PATIENTS. EKB Journal Management System, 2022; 39(1): 112-122. doi: 10.21608/bmfj.2022.17612.1083

CARBETOCIN VERSUS OXYTOCIN IN THE PREVENTION OF POSTPARTUM HEMORRHAGE FOLLOWING VAGINAL DELIVERY IN HIGH RISK PATIENTS

Benha Medical Journal
Article 8, Volume 39, Issue 1, March and April 2022, Page 112-122  XML PDF (746.01 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2022.17612.1083
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Authors
Mahmoud Abdulla Abdel Fatah1; khaled Mohamed Salama2; Yehia Mohamed Samir Edris2; Amany Mostafa Metwally email 3
1Obstatric and gynaecology department,Faculty of Medicne,Benha University,Benha,Egypt
2Obstetrics and Gynecology , Faculty of Medicine,Benha University,Benha,Egypt
3Obstetrics and Gynecology ,Faculty of Medicine, Benha University,benha, Egypt
Abstract
Background: Postpartum hemorrhage is a life threatening situation and one of the important causes of maternal mortality and morbidity, worldwide.
Aim of the work: To compare the efficacy of carbetocin and oxytocin in preventing postpartum hemorrhage following vaginal delivery in high risk groups.
Patients and methods: 120 women with gestational age between 37-40 weeks at high risk for primary atonic postpartum hemorrhage and delivered vaginally were randomly divided into two groups. First group: included 60 women, they received carbetocin, 100 mcg IM. Second group: included 60 women, they received Oxytocin 5 IU IM. Both groups received their drug after fetal and before placental delivery.
Results: There was a statistically significant difference between the two study groups regarding mean blood loss (276.93 ± 120.87 versus 346.42 ± 176.61), occurrence of PPH (3.3% versus 13.3%), hemoglobin and hematocrit difference between before and 24 h after delivery (0.55 ± 0.51 versus 0.998 ± 0.69, p= 0.002) (3.38 ±2.92 versus 4.65±4.18, p= 0.002) respectively and measured hemoglobin and hematocrit 24 h after delivery (being higher in carbetocin group). The effect of carbetocin as regard to estimated blood loss was more obvious in multiparous women. However, there was no significant difference between the two groups regarding need for other uterotonics, the need for blood transfusion and occurrence of nausea, vomiting, abdominal pain, flushing, tachycardia, hypotension, headache, itching and metallic taste.
Conclusions: Carbetocin is a better alternative to oxytocin in prevention of PPH after vaginal delivery with similar side effects.
Keywords
Carbetocin; oxytocin; postpartum hemorrhage
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