Ficolin-2 a newmarker for severity of liver inflammation in patients with chronic hepatitis C | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 24, Volume 73, Issue 11, October 2018, Page 8047-8053 PDF (335.88 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2018.21914 | ||||
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| Authors | ||||
Abd El Monem M. Barrak1; Hesham E. Lashin1; Mahmoud M. Metwally2; Nabil I. Abd El-Rahman  1
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| 1Internal Medicine Departments, Faculty of Medicine, Al –Azhar University (Cairo) | ||||
| 2Clinical Pathology Departments, Faculty of Medicine, Al –Azhar University (Cairo) | ||||
| Abstract | ||||
| Background: ficolin-2 is a kind of human serum complement lectin with a structure similar to mannan-binding lectin (MBL) and it has been implicated in innate immunity. Recent studies have shown that complement pathway activation may contribute to hepatitis. However, the relationship between ficolin-2 and viral hepatitis remains largely elusive. Aim of the work: this study aimed to determine the dynamics of ficolin-2 in patients with chronic hepatitis C. Patients and Methods: Thirty patients who had not yet received therapy and twenty normal control subjects were included in this study. A sandwich enzyme-linked immunosorbent assay (ELISA) was used to measure the ficolin-2 concentrations in all serum samples of patients and 20 healthy donors. Results: we found that the concentrations of ficolin-2 were significantly higher in chronic hepatitis C patients with abnormal ALT values than in chronic hepatitis C patients with normal ALT values and healthy controls. Ficolin-2 concentrations in chronic hepatitis C patients with abnormal ALT values were positively correlated with ALT levels (*P <0.05). Then, we found ficolin-2 concentrations in rapid viral response (RVR) group decreased significantly (*P <0.05), while in non-RVR group, ficolin-2 decreased slightly (P >0.05). Conclusion: our findings suggested that early increased ficolin-2 is highly correlated with hepatic inflammation and rapid viral response. | ||||
| Keywords | ||||
| ficolin-2; Liver inflammation; Chronic HCV | ||||
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