ANTI-GIARDIASIS EFFECT OF ZINGIBER OFFICINALE ON GIARDIA LAMBLIA INFECTION AND THE IMMUNOLOGICAL RESPONSE IN EXPERIMENTALLY INFECTED IMMUNOCOMPETENT MICE | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 1, Volume 49, Issue 1, April 2019, Page 1-10 PDF (970 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jesp.2019.219342 | ||||
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| Author | ||||
| ZAKIAH NASSER ALMOHAWES | ||||
| Department of Biology, Faculty of Science, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia | ||||
| Abstract | ||||
| Giardia lamblia is a common protozoan parasite infects humans and is the most common cause of waterborne outbreaks of diarrhoeal diseases. The present study examined the anti-giardiasis effective-ness of ginger as a natural product in the prevention and treatment of G. lamblia in infected mice. Male albino mice were divided into the following four groups: 1. Control uninfected untreated, 2. In-fected with Giardia cysts and untreated, 3. Prophylactic with ginger before infection, and 4. Treated with ginger after infection. The results showed that Ginger resulted in a complete eradication of Giar-dia cysts in the faeces after infection by day 12 in the protected group and day 10 in the treated group. IFN-γ levels were significantly decreased (p < 0.05) in the ginger-protected and ginger-treated groups, and IL-5 levels were elevated in both ginger groups. Histopathological observations of the ileum sup-port the immunological findings | ||||
| Keywords | ||||
| Saudi Arabia; Anti-giardiasis lamblia; Ginger; Zingiber officinale; IFN-γ; IL-5 | ||||
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