The prevalence of HBG2 polymorphism among Beta Thalassemia major Children in El Minia Governorate and its correlations with HbF level.
El Sherif, A., Salah, K., Hegazi, A., Elfateh, R. (2020). The prevalence of HBG2 polymorphism among Beta Thalassemia major Children in El Minia Governorate and its correlations with HbF level.. EKB Journal Management System, 31(3), 24-26. doi: 10.21608/mjmr.2022.219854
Ahmad A. El Sherif; Khaled M. Salah; Aliaa M. Monir Hegazi; Rania W. Mostafa Elfateh. "The prevalence of HBG2 polymorphism among Beta Thalassemia major Children in El Minia Governorate and its correlations with HbF level.". EKB Journal Management System, 31, 3, 2020, 24-26. doi: 10.21608/mjmr.2022.219854
El Sherif, A., Salah, K., Hegazi, A., Elfateh, R. (2020). 'The prevalence of HBG2 polymorphism among Beta Thalassemia major Children in El Minia Governorate and its correlations with HbF level.', EKB Journal Management System, 31(3), pp. 24-26. doi: 10.21608/mjmr.2022.219854
El Sherif, A., Salah, K., Hegazi, A., Elfateh, R. The prevalence of HBG2 polymorphism among Beta Thalassemia major Children in El Minia Governorate and its correlations with HbF level.. EKB Journal Management System, 2020; 31(3): 24-26. doi: 10.21608/mjmr.2022.219854

The prevalence of HBG2 polymorphism among Beta Thalassemia major Children in El Minia Governorate and its correlations with HbF level.

Minia Journal of Medical Research
Volume 31, Issue 3, July 2020, Page 24-26  XML PDF (376.1 K)
Document Type: Original Article
DOI: 10.21608/mjmr.2022.219854
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Authors
Ahmad A. El Sherif; Khaled M. Salah; Aliaa M. Monir Hegazi; Rania W. Mostafa Elfateh
Department of Clinical Pathology, El-Minia Faculty of Medicine
Abstract
Fetal hemoglobin (HbF) is the major modifier for thalassemia severity. HbF is modulated mainly by 
three major quantitative trait loci (QTL). One of the SNPs in these loci is HBG2. Thirty seven patients 
with beta thalassemia major from pediatric hematology unit of Minia University hospital, Minia were 
investigated by a panel of primers and probes using Polymorphism strip assay (β-Thal Modifier 
StripAssay) Vienna lab. In our study the frequency of wild CC genotypes were 31 patients (83.8%), 5 
patients (13.5%) were heterozygous CT and only 1 patient (2.7%) was homozygous TT. We also 
reveled significant association between HBG2 and Hb F level in beta thalassemia major patients in 
Minia governorate children. 

Keywords
Fetal hemoglobin; thalassemia; pediatric hematology
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