Metabolic Disorders in Obstructive Sleep Apnea Patients | ||||
| Minia Journal of Medical Research | ||||
| Volume 31, Issue 3, July 2020, Page 27-36 PDF (445.54 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2022.219855 | ||||
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| Authors | ||||
| Ahmed H. Kasem1; Mahmoud M. Higazi1; Aly O. Abdelaziz2; Rabab. A Sedeek.1 | ||||
| 1Department of Diagnostic Radiology, Faculty of Medicine, Minia University, Minia, Egypt | ||||
| 2Department of Diagnostic Radiology, Faculty of Medicine, Minia University, Minia, Egypt. | ||||
| Abstract | ||||
| Background :Obstructive sleep apnea (OSA) is a common chronic disorder with a prevalence of 2– 4% in general with an approximate rate of 14% in men and 5% in women aged (30–70) years respectively [1] . OSA is diagnosed according to clinical symptoms and episode of apnea-hypopnea measured via polysomnography (PSG). OSA is a worldwide highly prevalent disease associated with systemic consequences, including excessive sleepiness, neurocognitive dysfunction and daytime performance. The long-term sequelae of OSA lead to cardiovascular, cerebrovascular and metabolic syndrome disorders that lead to premature death if untreated[2] . Objective: This study aimed to determine metabolic syndrome comorbidities associated with OSA patients. Results: ninety (90) subjects were involved in this study 45 volunteers as a control ,45 patients with OSA (6 mild, 14 moderate, and 25 severe), their ages Mean±SD 57.2±8.9, 33.3% males, and 66.7% females, 24.4% current smoker, 8.9% ex-smoker, and 66.7% non-smoker. BMI was significantly higher among OSA patients than obese and non-obese control groups (P= <0.001). Neck circumference was significantly large among OSA patients than control groups (P= <0.001). Comorbidities as hypertension and DM was significantly high among OSA patients than control groups (p= <0.001*). There was statistically significant increase in thioredoxin among OSA patient more than control non-obese group (P= 0.026*). Also; there was decrease in adiponectin in OSA patients more than control obese and nonobese but in non-significant manner. There was statistically significant decrease in adiponectin with sever OSA more than moderate and mild groups (P= 0.022*). Conclusion: OSA is a serious condition that can be diagnosed with polysomnography and is associated with cardiovascular and metabolic comorbidities. | ||||
| Keywords | ||||
| Obstructive sleep apnea; metabolic syndrome; cardiovascular diseases; hypertension; diabetes; thioredoxin; and adiponectin | ||||
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