Study of the Role of Vitamin D in Non-Alcoholic Fatty Liver Disease in Male Albino Rats | ||||
Minia Journal of Medical Research | ||||
Volume 31, Issue 3, July 2020, Page 37-42 PDF (452.88 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/mjmr.2022.219856 | ||||
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Authors | ||||
Mariam Y. Ibrahim; Merhan M. Ragi; Heba A. Abd El-Hamid; Sally . W. Ayed | ||||
Department of Physiology, El-Minia Faculty of Medicine | ||||
Abstract | ||||
Background: Non-alcoholic fatty liver disease (NAFLD) is a very common cause of chronic liver disease. High fat diet (HFD) has been widely used to induce NAFLD in rats as obesity is a major cause of this disease. Vitamin D receptor was found in most tissues and cells of the body. It has been estimated that VDR regulates over 200 genes involved in glucose and lipid metabolism, inflammation, cellular proliferation, differentiation and apoptosis besides the classical skeletal functions of vitamin D. Objective: This work aimed to study the possible role of Vitamin D on the progression of nonalcoholic liver disease (NAFLD) in male albino rats and its possible mechanisms of action. Materials and methods: thirty adult male albino rats of local strain were used. They were divided into three groups; control group, high fat diet group (HFD) and high fat diet treated with vitamin D group (HFD+V.D). Serum liver enzymes, tumor necrosis factor-α (TNF-α) and B Cell Leukemia protein-2 (BCL2) level in liver tissue were measured in addition to histo-pathological examination of liver tissue. Results: HFD diet fed rats showed vacuolated hepatocytes with necro-inflammatory foci in histopathological examination along with elevated liver enzymes, TNF-α level in their serum and reduced BCL2 level in their liver tissue. Meanwhile rats treated with vitamin D showed reduction in fat vacuoles in liver sections and decreased inflammation along with reduced levels of liver enzymes and TNF-α in the serum and elevated levels of BCL2 in liver tissue. Conclusion: vitamin D has antiinflammatory and anti-apoptotic effects on HFD induced NAFLD. | ||||
Keywords | ||||
NAFLD; vitamin D; HFD; anti-inflammatory; anti-apoptotic | ||||
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