Evaluation of The Diagnostic Value of Brain Natriuretic Peptide for Detection of Left Ventricular Systolic Dysfunction and Pulmonary Hypertension in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 157, Volume 86, Issue 1, January 2022, Page 968-972 PDF (788.24 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2022.219974 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Hamdy Abdel Azeem; Mohamed S. Zaghlol  ; Ahmed Lotfi
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| Abstract | ||||
| Background: One of the most critical health concerns of our day is acute deterioration of chronic obstructive lung disease (COPD). Detecting concurrent heart illness in these individuals might be challenging. Objective: Aims of this study were determining the diagnostic value of B-type natriuretic peptide (BNP) levels in the identification of acute COPD exacerbations (AECOPD) that were linked with left ventricular (LV) dysfunction and pulmonary hypertension. Methods: a prospective study of 100 patients with acute COPD exacerbations was done. All research participants were subjected to history taking, clinical examination, laboratory testing, blood gas analysis, echocardiography, and NT-pro BNP plasma level estimation. Results: Receiver operating characteristic (ROC) curve for BNP as a diagnostic for LV systolic dysfunction showed that area under the curve (AUC) was 0.923 at cut off point of 72.1 ng/ml with sensitivity of 93.3% and specificity of 84.6% (P<0.001). Conclusion: Heart failure is confirmed when the average natriuretic (NT)-BNP level in the left ventricle during AECOPD is higher than normal, which should prompt quick treatment for both conditions. | ||||
| Keywords | ||||
| Acute exacerbation of COPD; Brain natriuretic peptide; Cardiac dysfunction; Pulmonary hypertension | ||||
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