Efficacy of morphine sulphate versus nalbuphine during functional endoscopic sinus surgery on intra-operative bleeding:A prospective, randomized, double blind study
Rashwan, D., Hassan, W., El-Gebaly, H. (2020). Efficacy of morphine sulphate versus nalbuphine during functional endoscopic sinus surgery on intra-operative bleeding:A prospective, randomized, double blind study. EKB Journal Management System, 31(3), 177-192. doi: 10.21608/mjmr.2022.220256
Doaa A. Rashwan; Wael F. Hassan; Hend R. El-Gebaly. "Efficacy of morphine sulphate versus nalbuphine during functional endoscopic sinus surgery on intra-operative bleeding:A prospective, randomized, double blind study". EKB Journal Management System, 31, 3, 2020, 177-192. doi: 10.21608/mjmr.2022.220256
Rashwan, D., Hassan, W., El-Gebaly, H. (2020). 'Efficacy of morphine sulphate versus nalbuphine during functional endoscopic sinus surgery on intra-operative bleeding:A prospective, randomized, double blind study', EKB Journal Management System, 31(3), pp. 177-192. doi: 10.21608/mjmr.2022.220256
Rashwan, D., Hassan, W., El-Gebaly, H. Efficacy of morphine sulphate versus nalbuphine during functional endoscopic sinus surgery on intra-operative bleeding:A prospective, randomized, double blind study. EKB Journal Management System, 2020; 31(3): 177-192. doi: 10.21608/mjmr.2022.220256

Efficacy of morphine sulphate versus nalbuphine during functional endoscopic sinus surgery on intra-operative bleeding:A prospective, randomized, double blind study

Minia Journal of Medical Research
Volume 31, Issue 3, July 2020, Page 177-192  XML PDF (452.71 K)
Document Type: Original Article
DOI: 10.21608/mjmr.2022.220256
View on SCiNiTO View on SCiNiTO
Authors
Doaa A. Rashwan1; Wael F. Hassan2; Hend R. El-Gebaly1
1Department of Anaesthesia, Surgical ICU and Pain management, Faculty of Medicine, Beni- Suef University, Egypt
2Department of Anaesthesia, Surgical ICU and Pain management, Faculty of Medicine, Beni- Suef University, Egypt.
Abstract
The goal of this study is to compare the efficacy of morphine with that of nalbuphine on intraoperative bleeding in FESS operations. 68 patients, between 20 to 50 years old, were randomly 
grouped into two groups, 34 in each group. Group 1: received morphine 0.1 mg/ kg i.v 30 min before 
induction of anaethesia and group 2: received nalbuphine 0.1 mg/ kg i.v 30 min before induction. 
Both groups received nitroglycerin ( 0.5 – 10) mcg/kg/min at the start of procedure. Both drugs were 
successful to achieve a decrease in MABP with a significant statistical difference after 5, 15, 30, 45 
min, with no significant difference after 45,60,75, 90 and 105 min. There was no statistical significant 
difference between both drugs concerning the HR all over the procedure time. Morphine group 
needed lesser doses of nitroglycerine than nalbuphine group to achieve hypotensive anaesthesia with a 
statistical significant difference. No significant differences found between both groups concerning 
bleeding loss, post operative side effects (nausea, vomiting, shivering), surgeon satisfaction score, 
sedation score or recovery time.

Keywords
Morphine; Nalbuphine; nitroglycerine; hypotensive anaesthesia; FESS; intra-operative  bleeding
Supplementary Files
Statistics
Article View: 123
PDF Download: 192