Trefoil 2 level in chronic kidney disease | ||||
Minia Journal of Medical Research | ||||
Volume 31, Issue 3, July 2020, Page 206-215 PDF (557.43 K) | ||||
DOI: 10.21608/mjmr.2022.220268 | ||||
View on SCiNiTO | ||||
Authors | ||||
Noha M. Abdullah1; Ashraf M. Osman1; Emad A. Abd-Elnaeem1; Basma Fathy2; Rehab F. Mohammed1 | ||||
1Department of Clinical Pathology, El-Minia Faculty of Medicine | ||||
2Department of Internal Medicine, El-Minia Faculty of Medicine | ||||
Abstract | ||||
Objective: To detect the role of trefoil factor (TF2)(in both serum and urine) in different stage of CKD. Study design: A total of 40 patients with CKD and 20 apparently healthy volunteers (as control group) were eligible for the study. Patients group was subdivided into 3 subgroups {Mild (13), Moderate (13) and late group (14)}.Complete Blood Count(CBC),kidney function tests,Urine Protein /creatinine ratio ( P/C Ratio),Estimated glomerular filtration rate (eGFR), Serum and urine TF2 were done to all subjects. Results: Patients groups exhibited higher seruumTF2 concentrations (371.5 pg/ml) than control group (2 pg/ml). A significant increase in serum.TF2 level in group III when compared to group I, group II and group IV (p value= <0.001). Also, serum TF2 was significantly higher in group II when compared to group I and group IV (P value= <0.001). In addition there was significant increase in group I when compared to group IV (p value= <0.001).As regard urine TF it was higher in patients groups (460 pg/ml) than control group (2 pg/ml).A significant decrease in urine.TF2 level in group III when compared to group I, group II and group IV (p value= <0.001). Also, urine TF2 was significantly decrease in group II when compared to group I and group IV (p value= <0.001). But urine TF2 was significant increase in group I when compared to group IV (p value= <0.001). Conclusion: The data suggest the role of TF2 concentration (in urine and serum) to detect the stage of CKD. Serum TF2 concentrations increased progressively in later stages than early and moderated stage. Urine TF2 levels were significantly higher in early and mid CKD stages as compared to later stages. | ||||
Keywords | ||||
Chronic kidney disease (CKD); Estimated glomerular filtration rate (eGFR); Serum TFF2; Urine TFF2 | ||||
Statistics Article View: 76 PDF Download: 103 |
||||