Histological Study of Toxic Effects of Acrylamide on the Liver and Kidney of Adult Male Albino Rats | ||||
| Minia Journal of Medical Research | ||||
| Volume 31, Issue 3, July 2020, Page 345-350 PDF (511.96 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2022.220316 | ||||
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| Authors | ||||
| Azza , H. Ali; Randa . A Ibrahim; Amira F. Ahmed; Esraa M. Khairy Talaat. | ||||
| Department of Histology, El-Minia Faculty of Medicine | ||||
| Abstract | ||||
| Background and objectives: Acrylamide has become one of the important public health concerns as it was detected in widely consumed food items; for example, fried bread, potato chips, any carbohydrate-rich food products cooked at high temperatures, roasted coffee. Several health hazards were reported after acrylamide exposure in animal and human models. Many studies reported that acrylamide can induce toxicity to many body organs such as reproductive toxicity, genotoxicity and neurotoxicity. Materials and methods: Forty adult male albino rats were randomly divided into 2 groups (n=10 per group). The control group (group I): received only standard diet and drinking water for 6 weeks. The acrylamide group (group II): received acrylamide via in tragastric gavage route at dose of 20 mg/kg once daily for 6 weeks. Histological and examination of the liver and kidney was done. Results: There were marked structural changes in kidney and liver of group II in the form of congestion apoptosis and vacuolations if compared to the control group. Conclusion: Administration of acrylamide continuously for six weeks causes massive destruction in both liver and kidney. | ||||
| Keywords | ||||
| Acrylamide; public health; body organs | ||||
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