Relation between Level of Transforming Growth Beta-1 and Micro-vascular Diabetic complications
Hassan, S., Hamdy, S., Othman, O., Sayed, A. (2022). Relation between Level of Transforming Growth Beta-1 and Micro-vascular Diabetic complications. EKB Journal Management System, 14(1), 143-152. doi: 10.21608/eajbsc.2022.220568
Shaimaa H. M. Hassan; Soha Hamdy; Othman M. A. Z. Othman; Alaa R. M. Sayed. "Relation between Level of Transforming Growth Beta-1 and Micro-vascular Diabetic complications". EKB Journal Management System, 14, 1, 2022, 143-152. doi: 10.21608/eajbsc.2022.220568
Hassan, S., Hamdy, S., Othman, O., Sayed, A. (2022). 'Relation between Level of Transforming Growth Beta-1 and Micro-vascular Diabetic complications', EKB Journal Management System, 14(1), pp. 143-152. doi: 10.21608/eajbsc.2022.220568
Hassan, S., Hamdy, S., Othman, O., Sayed, A. Relation between Level of Transforming Growth Beta-1 and Micro-vascular Diabetic complications. EKB Journal Management System, 2022; 14(1): 143-152. doi: 10.21608/eajbsc.2022.220568

Relation between Level of Transforming Growth Beta-1 and Micro-vascular Diabetic complications

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology
Article 13, Volume 14, Issue 1, June 2022, Page 143-152  XML PDF (755.3 K)
Document Type: Original Article
DOI: 10.21608/eajbsc.2022.220568
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Authors
Shaimaa H. M. Hassan1; Soha Hamdy1; Othman M. A. Z. Othman2; Alaa R. M. Sayed1
1Department of Biochemistry, Faculty of Science, Fayoum University.
2Department of Clinical Pathology, Faculty of Medicine, Fayoum University
Abstract
Background:  Diabetes mellitus (DM) is a collection of metabolic illnesses marked by chronic hyperglycemia caused by insulin production, insulin action, or both. Diabetes is classified into three types: type 1 diabetes (T1DM), type 2 diabetes (T2DM), and gestational diabetes (GDM). Diabetic nephropathy, diabetic retinopathy, and diabetic neuropathy are examples of microvascular complications of diabetes. TGF-1 (transforming growth factor-beta 1) is one of the most important cytokines involved in the regulation of extracellular matrix (ECM) synthesis and degradation. Aim of this study: Is to illustrate the relation between the level of serum TGF-β1 in patients with type II diabetes with and without micro-vascular complications. Subjects and methods: All 90 enrolled study subjects were divided into 3 groups. Group 1: (n=30), healthy controls, group 2: (n=30) T2DM patients without microvascular complications, and group 3: (n=30) T2DM patients with microvascular complications. Those patients were collected from Fayoum University Hospital. All patients and controls are subjected to routine laboratory tests including (performed on Beckman coulter, AU-480); fasting and postprandial blood glucose, serum creatinine, glycosylated hemoglobin, and lipid profile. Serum TGF- β1 level was measured by an ELISA kit.Results:  There is a statistically significant difference (P -value P -value P-value <0.001) among diabetic with microvascular diabetic complications group followed by diabetic and lower mean among control. There is a statistically significant positive correlation (P-value <0.05) between TGF-β1 and each of HDL, age, and creatinine levels which indicated an increase in LDL, and creatinine levels will be associated with an increase in TGF- β1 among all studied groups. There is a statistically significant difference (P-value <0.001) between all studied groups as regards mean creatinine level with highest mean among diabetic with microvascular complications group followed by diabetic and lower mean among control. Conclusion: This study indicated that the serum TGF-β1 level in T2DM patients with microvascular complications was significantly increased compared to T2DM patients without microvascular complications. 
Keywords
DM; Micro-vascular diabetic complications; TGF-β1
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