Histological Study of the Damaging Effect Induced by Cyclophosphamide on Intestinal Mucosa of Adult Male Albino Rat | ||||
| Minia Journal of Medical Research | ||||
| Volume 32, Issue 1, January 2021, Page 56-61 PDF (801.91 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2022.220582 | ||||
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| Authors | ||||
| Sara M. Abdel-Hafez; Nashwa F. Eltahawy; Rasha M. Tantawi; Soha A. Abdel- Wahab | ||||
| Department of Histology, El-Minia Faculty of Medicine | ||||
| Abstract | ||||
| Background and objectives: Cyclophosphamide is an effective anti-cancer drug widely used in the treatment of many types of cancers, e.g., acute and chronic leukemia, lymphomas, breast cancer, ovarian cancer, neuroblastoma, and sarcoma. It is also used in immunosuppression disorders. Several health hazards were reported after cyclophosphamide administration in animal and human models. Many adverse effects are related to cyclophosphamide and include chemotherapy-induced nausea and vomiting, bone marrow suppression, stomach ache, hemorrhagic cystitis, diarrhea, darkening of the skin and alopecia (hair loss). Materials and methods: Twenty- four adult male albino rats were divided into 2 groups (n=12 per group). The control group (C-group), received only standard diet and water. The cyclophosphamide 2 weeks group (CP-2W), received intraperitoneal injection of a single sublethal dose of 300 mg /kg body weight and rats were sacrificed after 2 weeks. Results: There were marked structural changes in intestinal mucosa of CP-2D group in the form of Inflammation, degenerative changes and apoptosis. Conclusion: Single intraperitoneal injection of cyclophosphamide causes massive distruction in the intestinal mucosa. | ||||
| Keywords | ||||
| Cyclophosphamide; anti-cancer drug; massive distruction | ||||
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