Prevalence of Multi-drug resistant Escherichia coli isolated in neonatal intensive care units in a local hospital, Minia, Egypt | ||||
| Minia Journal of Medical Research | ||||
| Volume 31, Issue 2, April 2020, Page 54-58 PDF (418.28 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2022.220836 | ||||
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| Authors | ||||
| Eman M. Senosy1; Reham A. Ibrahim2; Rehab M. Abd El-Baky1 | ||||
| 1Department of Microbiology and Immunology, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt. | ||||
| 2Department of Microbiology and Immunology, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt | ||||
| Abstract | ||||
| Neonatal sepsis is a leading cause of neonatal mortality in developing countries. Identification of the etiological agents of neonatal sepsis is essential for effective treatment. Out of 462 cases, 140 neonates had signs of sepsis, a total of 114/140 (81.4%) samples were positive for microbial growth. Gram positive cocci and Gram negative rods were isolated at the same rate (57/114, 50 % each) but E. coli was the most common (35.9%), followed by S. aureus (23.6%), coagulase negative Staphylococci (CONS) (20.11%). In addition, E. coli isolates showed highest resistance to cefotaxime (100%), linezolid (100%), ampicillin (97.5%), amoxicillin-clavulanic acid (97.5%), aztreonam (97.5%), cefepime (97.5%), meropenem (97.5), ampicillin-sulbactam,(82.9%), amikacin (75.6%), gentamicin (73.1%), piperacillin-tazobactam (73.1%) and ciprofloxacin (60.9%), least resistance was found to imipenem (34.1%) and azithromycin (34.1%). Also, of 41 E. coli isolates harbored 20 hly A genes, giving a 165-bp band and 19 fim H genes, giving a 508-bp band as shown by PCR. | ||||
| Keywords | ||||
| Neonatal sepsis; neonatal mortality; etiological agents; Escherichia coli | ||||
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