Apelin and Procalcitonin in Neonatal Sepsis | ||||
| Minia Journal of Medical Research | ||||
| Volume 31, Issue 2, April 2020, Page 59-64 PDF (265.01 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2022.220837 | ||||
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| Authors | ||||
| Lamia H. Ali; Ahmed A. Saedii; Mohammed A. Abdel Hakeem | ||||
| Department of Clinical Pathology, El-Minia Faculty of Medicine | ||||
| Abstract | ||||
| Introduction: The identification and treatment of sepsis continues to be a major health issue. The incidence of sepsis is particularly high in the neonatal population. Aim of the work: The aim of the present study is to evaluate the role of apelin in neonatal sepsis and its relation with other biomarkers as procalcitonin and blood culture results. Subjects and Methods: This study included 90 neonates divided into two groups: Group I: included 60 neonates with clinically sepsis diagnoised according to (Thaver and Zaidi, 2009) who were subgrouped into group I a (EOS) (early onset ≤ 72h) included 36 neonates and group I b (LOS) ( late onset > 72) included 24 neonates. Results: The study was carried out on 90 neonates divided into two groups: Group I : included 60 neonates with clinically sepsis and subgrouped according to onset of sepsis into group I a (early onset ≤ 72h) included 36 neonates and group I b (late onset > 72) included 24 neonates. They were selected from NICU (neonatal intensive care unit) of El-Minia Obstetric and Pediatric University Hospital from February to September 2015. Conclusion: Although blood culture is a gold standerd for diagnosis of neonatal sepsis, but we cannot depend on it only. Apelin and procalcitonin are reliable diagnostic markers of neonatal sepsis which have the same diagnostic accuracy. Apelin and procalcitonin are a good marker for early diagnosis of neonatal sepsis but Apelin is more perfect marker than procalcitonin in diagnosis of early neonatal sepsis. The use of apelin and other markers (procalcitonin, CRP, TLC, platlets and blood culture ) collectively yeild the best results for diagnosis of neonatal sepsis. | ||||
| Keywords | ||||
| Apelin; Procalcitonin; Neonatal Sepsis | ||||
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