Immunohistochemical Expression of Claudin-4 in Invasive Ductal Carcinoma of the Breast
Abd El-Rehim, D., Safwat, R., Khalil, ,., Al-Azhary, R. (2020). Immunohistochemical Expression of Claudin-4 in Invasive Ductal Carcinoma of the Breast. EKB Journal Management System, 31(2), 79-87. doi: 10.21608/mjmr.2022.220842
Dalia M. Abd El-Rehim; Rabab A. Safwat; , Al Zahraa I. Khalil; Reham D. Al-Azhary. "Immunohistochemical Expression of Claudin-4 in Invasive Ductal Carcinoma of the Breast". EKB Journal Management System, 31, 2, 2020, 79-87. doi: 10.21608/mjmr.2022.220842
Abd El-Rehim, D., Safwat, R., Khalil, ,., Al-Azhary, R. (2020). 'Immunohistochemical Expression of Claudin-4 in Invasive Ductal Carcinoma of the Breast', EKB Journal Management System, 31(2), pp. 79-87. doi: 10.21608/mjmr.2022.220842
Abd El-Rehim, D., Safwat, R., Khalil, ,., Al-Azhary, R. Immunohistochemical Expression of Claudin-4 in Invasive Ductal Carcinoma of the Breast. EKB Journal Management System, 2020; 31(2): 79-87. doi: 10.21608/mjmr.2022.220842

Immunohistochemical Expression of Claudin-4 in Invasive Ductal Carcinoma of the Breast

Minia Journal of Medical Research
Volume 31, Issue 2, April 2020, Page 79-87  XML PDF (1.02 MB)
Document Type: Original Article
DOI: 10.21608/mjmr.2022.220842
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Authors
Dalia M. Abd El-Rehim1; Rabab A. Safwat2; , Al Zahraa I. Khalil2; Reham D. Al-Azhary2
1Department of Pathology, Faculty of Medicine, Minia University, Egypt
2Department of Pathology, Faculty of Medicine, Minia University, Egypt.
Abstract
Background: Breast carcinoma is a major public health problem. Claudins are important tight 
junction proteins, they came into focus for their suggested role in carcinogenesis and possible role in 
cancer therapy. To date, few studies have addressed the role of claudins in BC. Claudin-4 has been 
found to be overexpressed in a wide variety of cancers including breast cancer, its role in BC 
progression and spread constitutes an active research focus. Methods: Immunohistochemical staining 
of claudin-4 was conducted on 50 tissue specimens of invasive ductal carcinoma of the breast (IDCNST) by using the avidin biotin-peroxidase complex method with diaminobenizidine (DAB) 
chromagen detection system. Results: High claudin-4 expression was detected in 52% of cases. 
Claudin-4 expression showed statistically significant association with tumor laterality, tumor grade, 
stage, advanced nodal status, LNR, NPI, Ki67 PI, ER& PR status and triple negative phenotype (p.= 
0.008, 0.027, 0.016, 0.043, 0.006, 0.006, <0.001, 0.014, 0.019 and 0.047 respectively). On comparing 
claudin-4 expression in 12 pairs of primary IDC-NST and their corresponding LN metastasis, a 
concordance rate of 75% was found between primary tumors and their metastatic LNs where 9/12 
cases maintained the same expression score. Conclusions: Claudin-4 expression is suggested to be a 
molecular protein with an oncogenic function and biological value. Being involved in IDC-NST 
progression and its association with many poor prognostic factors of IDC-NST, the important role in 
progression and spread in invasive ductal breast carcinoma is highlighted. 

Keywords
Claudin-4; Breast Carcinoma; immunohistochemistry. 
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