The association of interleukin 6 single nucleotide polymorphism with the susceptibility of Egyptians to HCV infection
Abd El-Baky, R., Hetta, H., Fawzy, M., Fathy, M. (2020). The association of interleukin 6 single nucleotide polymorphism with the susceptibility of Egyptians to HCV infection. EKB Journal Management System, 31(2), 112-118. doi: 10.21608/mjmr.2022.220847
Reham M. Abd El-Baky; Helal F. Hetta; Michael A. Fawzy; Moustafa Fathy. "The association of interleukin 6 single nucleotide polymorphism with the susceptibility of Egyptians to HCV infection". EKB Journal Management System, 31, 2, 2020, 112-118. doi: 10.21608/mjmr.2022.220847
Abd El-Baky, R., Hetta, H., Fawzy, M., Fathy, M. (2020). 'The association of interleukin 6 single nucleotide polymorphism with the susceptibility of Egyptians to HCV infection', EKB Journal Management System, 31(2), pp. 112-118. doi: 10.21608/mjmr.2022.220847
Abd El-Baky, R., Hetta, H., Fawzy, M., Fathy, M. The association of interleukin 6 single nucleotide polymorphism with the susceptibility of Egyptians to HCV infection. EKB Journal Management System, 2020; 31(2): 112-118. doi: 10.21608/mjmr.2022.220847

The association of interleukin 6 single nucleotide polymorphism with the susceptibility of Egyptians to HCV infection

Minia Journal of Medical Research
Volume 31, Issue 2, April 2020, Page 112-118  XML PDF (446 K)
Document Type: Original Article
DOI: 10.21608/mjmr.2022.220847
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Authors
Reham M. Abd El-Baky1; Helal F. Hetta2; Michael A. Fawzy1; Moustafa Fathy3
1Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia, Egypt.
2Department of Microbiology and Immunology, Assuit university, Assuit, Egypt
3Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia, Egypt
Abstract
Background: Hepatitis C virus (HCV) is considered as a main leading cause for cirrhosis and hepatocellular carcinoma (HCC). We aimed to examine the association of IL-6 single nucleotide polymorphisms with the susceptibility of Egyptians to HCV infection. Patients and methods: For comparative purposes, four groups were enrolled; chronic HCV (CHC-group, n=22), HCV-related liver cirrhosis (HCV-LC-group, n= 22), HCV-related HCC (HCV-HCC-group, n=54) and an apparently healthy control group (Control-group, n=48). IL-6 rs-1474347 genotyping was performed using real time PCR assays. Results: For IL-6 rs1474347, AA genotype was more frequent in CHC, HCV-LC and HCV-HCC compared to controls. Conclusion: Screening for IL-6 rs 1474347 AC genotype is considered a good marker for testing the susceptibility of Egyptians to be susceptible for HCV infections and the progression of the disease.
Keywords
Hepatitis C virus; cirrhosis and hepatocellular carcinoma
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