Immunohistochemical Expression of PDL1 in Invasive Ductal Carcinoma of the Breast | ||||
| Minia Journal of Medical Research | ||||
| Volume 31, Issue 2, April 2020, Page 122-127 PDF (352.47 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2022.220849 | ||||
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| Authors | ||||
| Nehad M. Reda1; Nisreen A. Abd El Gaber1; Maram A. Mohammedan2; Ola N. Mohammed1 | ||||
| 1Department of Pathology, Faculty of Medicine, Minia University, Egypt. | ||||
| 2Department of Pathology, Faculty of Medicine, Minia University, Egypt | ||||
| Abstract | ||||
| Background: Breast cancer is the most common diagnosed cancer among females and the leading cause of cancer deaths. Immunohistochemical expression of PDL1 has been associated with bad prognosis in various malignancies including breast cancer. Methods: Immunohistochemical staining of PDL1 was performed on 60 tissue specimens of invasive ductal carcinoma by using the avidin biotin-peroxidase complex method with diaminobenizidine (DAB) chromogen detection system. Results: High expression of PDL1 was detected in tumor cells in 51.7% of cases. High expression was statistically significant with high tumor grade (p<0.001), LVI (p=0.002), infiltrated tumor margins (p=0.039), LN metastasis (p=0.013), ER- status (p=0.012), PR- status (p=0.002) and high Ki-67 expression (p=0.031). Conclusion: High PDL1 expression in tumor cells was associated with poor prognostic factors as high tumor grade, LVI, infiltrated tumor margins, LN metastasis and high Ki-67 expression. Overexpression of PDL1 is related to bad outcome of invasive ductal carcinoma cases. | ||||
| Keywords | ||||
| PDL1; Invasive ductal carcinoma; Immunohistochemistry | ||||
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