Histological study on the Effect of Selenium Nanoparticles on Cadmium-induced Thyrotoxicity in Adult Male Albino Rat | ||||
| Minia Journal of Medical Research | ||||
| Volume 31, Issue 2, April 2020, Page 166-181 PDF (1.35 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2022.220857 | ||||
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| Authors | ||||
| Dalia H. Abdel-Aziz Helmy; Azza S. Moawad Embaby; Fatma Alzahraa M. Abdel Lattif; Mohamed l. Abdel-Aziz Ali | ||||
| Department of Medical Histology & Cell Biology, Faculty of Medicine, Beni-Suef University, Egypt | ||||
| Abstract | ||||
| Back ground: Cadmium is a widespread and serious material that leads to different harmful cellular changes up to death. Se is a well-known element for its antioxidant role in living systems of humans and animals. Selenium nanoparticles have the ability to act as an antioxidant with reduced risk of ordinary selenium toxicity. Aim of work: is to investigate the effect of Selenium nanoparticles on cadmium induced thyrotoxicity in adult male albino rats. Material and methods: A total of 38 adult male albino rats were divided into four groups. The control group (8 rats) was given only distilled water for 35 days; the cadmium-treated group was given CdCl2 in their drinking water for 35 days; the nanoselenium-treated group was given Na2SeO3 in their drinking water for 35 days and the nanoselenium-cadmium-treated group was given Na2SeO3 and CdCl2 in their drinking water for 35 days. The animals of all groups were sacrificed at the same time and their thyroid glands were rapidly dissected out. The specimens of each group were processed for light and immunohistochemical studies. They were stained with hematoxylin and eosin, masson's trichrome, and inducible nitric oxide synthase. Quantitative morphometric, and statistical studies were performed. Results: Picture of cytotoxicity was visible in cadmium-treated thyroid sections in the form of disorganized follicles of varying diameters, with a predominance of smaller follicles. The follicular epithelial cells appeared to be enlarged and had a vacuolated cytoplasm. In addition to reduced or absent colloid. The thyroid gland of nanoselenium–cadmium-treated animals showed a nearly normal follicular structure. Conclusion: In experimental animal the administration of nanoselenium in response to an increased risk of exposure to cadmium compounds has a protective effect against their harmful effects. | ||||
| Keywords | ||||
| cadmium; rats; nanoselenium; thyroid gland | ||||
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