Coordination Behavior and Biological Activity of Some Transition Metal Complexes with p-nitrophenyl and phenylazo 2, 6 diaminopyridine | ||||
| Assiut University Journal of Multidisciplinary Scientific Research | ||||
| Volume 48, Issue 1, June 2019, Page 16-34 PDF (532.18 K) | ||||
| Document Type: Novel Research Articles | ||||
| DOI: 10.21608/aunj.2019.220881 | ||||
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| Abstract | ||||
| The objective of this study is to synthesize, characterize and evaluate the biological activity of p-nitrophenylazo and phenylazo 2,6-diaminopyridine and their Co(II)-, Ni(II)- and Cu(II)-chelates. The newly formed metal chelates were characterized by elemental analysis, FT-IR, mass and 1HNMR spectra, thermogravimetric analysis (TGA) and biological activity. The electronic absorption spectra and magnetic susceptibility measurements refer to an octahedral geometry structure of the prepared complexes. The antibacterial and antifungal activities of the ligands and its metal complexes were examined against bacterial species (Staphylococcus aureus, Bacillus subtilis and Escherichia coli) and fungi (Candida albicans). Ampicillin and amphotericin were used as references for antibacterial and antifungal studies. The activity data show that the metal complexes have a conscious biological activity that can be compared with the parent free ligands against bacterial and fungal species. | ||||
| Keywords | ||||
| Azo 2; 6-diaminopyridine; transition metal complex; antibacterial activity | ||||
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