Nigella sativa L. as a potential natural product for the treatment of COVID-19
Al Azzam, K., Al Omari, R., aburoub, A., Bekbayeva, L., Negim, E., aboulenein, H. (2022). Nigella sativa L. as a potential natural product for the treatment of COVID-19. EKB Journal Management System, 65(10), 141-151. doi: 10.21608/ejchem.2022.111517.5069
Khaldun Al Azzam; Rima Mohammad Al Omari; Adam aburoub; Lyazzat Bekbayeva; El-Sayed Moussa Negim; Hassan aboulenein. "Nigella sativa L. as a potential natural product for the treatment of COVID-19". EKB Journal Management System, 65, 10, 2022, 141-151. doi: 10.21608/ejchem.2022.111517.5069
Al Azzam, K., Al Omari, R., aburoub, A., Bekbayeva, L., Negim, E., aboulenein, H. (2022). 'Nigella sativa L. as a potential natural product for the treatment of COVID-19', EKB Journal Management System, 65(10), pp. 141-151. doi: 10.21608/ejchem.2022.111517.5069
Al Azzam, K., Al Omari, R., aburoub, A., Bekbayeva, L., Negim, E., aboulenein, H. Nigella sativa L. as a potential natural product for the treatment of COVID-19. EKB Journal Management System, 2022; 65(10): 141-151. doi: 10.21608/ejchem.2022.111517.5069

Nigella sativa L. as a potential natural product for the treatment of COVID-19

Egyptian Journal of Chemistry
Article 13, Volume 65, Issue 10, October 2022, Page 141-151  XML PDF (791.21 K)
Document Type: Review Articles
DOI: 10.21608/ejchem.2022.111517.5069
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Authors
Khaldun Al Azzam email orcid 1; Rima Mohammad Al Omariorcid 1; Adam aburoub1; Lyazzat Bekbayevaorcid 2; El-Sayed Moussa Negimorcid 3; Hassan abouleneinorcid 4
1Pharmacological and Diagnostic Research Center (PDRC), Department of Pharmaceutical Sciences, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan
2Biology Program, School of Distance Education, Universiti Sains Malaysia, Penang, Malaysia
3Laboratory of Advanced Materials and Technology, Kazakh-British Technical University, 59 Tole bi St., 050000, Almaty, Kazakhstan
4Pharmaceutical and Medicinal Chemistry Department, National Research Centre, Dokki, Giza 12311, Egypt
Abstract
The world is now facing a public health emergency caused by the coronavirus pandemic (COVID-19). The World Health Organization (WHO) has called it an emerging pandemic due to its sudden appearance and distribution. Coronavirus disease 2019 (COVID-19) is a pandemic caused by the Coronavirus2 of the Extreme Acute Respiratory Syndrome (SARS-CoV2). Nigella sativa (N. sativa) (Family Ranunculaceae) is a globally used medicinal herb. Unani and Tibb, Ayurveda, and Siddha are only a few of the western medical systems that use it. N. sativa, also known as black seed, is an essential medicinal plant that has long been used as a multipurpose medicinal agent in various countries. Immune deficiency, autophagy deficiency, oxidative stress, pathological inflammation, diabetes, cardiovascular diseases, and bacterial and viral infections are all treated effectively with the essential oil and other preparations of the N. sativa crop. It comprises of many essential groups of bioactive compounds, one of which, thymoquinone, has piqued the scientific community's interest due to its active function in treating a wide variety of diseases. The therapeutic effectiveness of N. sativa, as well as recent computational results, clearly suggest that it may be used to tackle the COVID-19 pandemic that has recently arisen. The aim of this review is to highlight the therapeutic importance of N. sativa in conventional medicine, as well as the potential for its use as an antiviral agent against the SARS-CoV2 virus and for further preclinical research.
Keywords
COVID-19; SARS-CoV2; Nigella sativa; natural products; World Health Organization; pandemic
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