Effects of Prenatal Stress Exposure on Stress Neurohormonal Axis in Rat Pups of Thyroid Disturbed Mothers | ||||
| Minia Journal of Medical Research | ||||
| Volume 31, Issue 2, April 2020, Page 261-271 PDF (1013.36 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2022.221058 | ||||
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| Authors | ||||
| Yasser M. Ashour1; Khaled A. Abd-El-Sater2; Ahmad A. Abdel-Hakeem3; Ahmmad R. Hamed1; Shimaa F. Abdel-Latif4 | ||||
| 1Department of physiology, Faculty of Medicine, Al-Azhar University, Assuit, Egypt | ||||
| 2Department of Physiology, Egyptian Russian University, ,Egypt, | ||||
| 3Department of physiology, Faculty of Medicine, Al-Azhar University, Assuit, Egypt. | ||||
| 4Department of Pathology, Faculty of Medicine, Sohag University, Egypt. | ||||
| Abstract | ||||
| Thyroid dysfunction during pregnancy is common. Maternal thyroid dysfunction is associated with an increased risk of various adverse maternal and child outcomes, including miscarriage, intrauterine growth retardation, hypertensive disorders, preterm delivery, and a decreased child IQ. During pregnancy, profound changes in thyroid physiology occur to provide sufficient thyroid hormone (TH) to both the mother and fetus. There is growing evidence demonstrating that thyroid hormone affects the various components of the hypothalamic–pituitary–adrenal (HPA) axis Therefore, this study was designed to investigate that maternal Thyroid dysfunction during pregnancy impaired feedback mechanisms of the HPA- axis and associated with thyroid disorders and neurobiological alterations in off sprigs. Therefore, 42 female wistar rats (200-250gm) after induction of pregnancy and hyperthyroxinemia and hypothyroxinemia. Their pups were divided into twelve groups (control nonstressed group, control stressed group hyperthyroid non-stressed group, treated non-stressed group, hyperthyroid stressed group, treated stressed group) and (control non-stressed group, control stressed group, hypothyroid non-stressed group, treated non-stressed group, control stressed group, hypothyroid stressed group, treated stressed group). Measurement of some hormones and histological analyses were done and result the induction of hyperthyroidism in mothers was significantly increased of plasma T4 and increased of plasma TSH levels in all pups group compared with control group. ACTH and Corticosterone increased in stressed group compared to other groups. In addition, hyperthyroid group showed small amount of colloid with irregular structure and architecture of the thyroid gland compared with treated and control group. Also induction of hypothyroidism in mothers was significantly decreased of plasma T4 and decreased of plasma TSH levels in all pups group compared with control group. ACTH and Corticosterone increased in stressed group compared to other groups. In addition, hyperthyroid group showed small amount of colloid with irregular structure and architecture of the thyroid gland compared with treated and control group, While that in the hypothyroid group; the amount of colloid increased and the height and activity of the follicular epithelium decreased, where as in the treated group the amount of colloid increased (abundant basophilic colloid) and the height and activity of the follicular epithelium increased. In conclusion, the effects of maternal stress exposure during pregnancy on HPA-axis regulation and anxiety-like behavior can be transferred via the maternal line to its offspring. | ||||
| Keywords | ||||
| Hyperthyroidism; Hypothyroidism; pregnancy; stress; HPA axis | ||||
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