The Effect of Anti-Oxidant and Iron Chelator on Metabolic E Bone Turnover in Ovariectomized Rats
El-Refaey, M., Ashour, Y., Abdelzaher, L., Shabaan, M. (2020). The Effect of Anti-Oxidant and Iron Chelator on Metabolic E Bone Turnover in Ovariectomized Rats. EKB Journal Management System, 31(2), 280-288. doi: 10.21608/mjmr.2022.221070
Mohamed E. El-Refaey; Yasser M. Ashour; Lobna A. Abdelzaher; Maher A. Shabaan. "The Effect of Anti-Oxidant and Iron Chelator on Metabolic E Bone Turnover in Ovariectomized Rats". EKB Journal Management System, 31, 2, 2020, 280-288. doi: 10.21608/mjmr.2022.221070
El-Refaey, M., Ashour, Y., Abdelzaher, L., Shabaan, M. (2020). 'The Effect of Anti-Oxidant and Iron Chelator on Metabolic E Bone Turnover in Ovariectomized Rats', EKB Journal Management System, 31(2), pp. 280-288. doi: 10.21608/mjmr.2022.221070
El-Refaey, M., Ashour, Y., Abdelzaher, L., Shabaan, M. The Effect of Anti-Oxidant and Iron Chelator on Metabolic E Bone Turnover in Ovariectomized Rats. EKB Journal Management System, 2020; 31(2): 280-288. doi: 10.21608/mjmr.2022.221070

The Effect of Anti-Oxidant and Iron Chelator on Metabolic E Bone Turnover in Ovariectomized Rats

Minia Journal of Medical Research
Volume 31, Issue 2, April 2020, Page 280-288  XML PDF (879.27 K)
Document Type: Original Article
DOI: 10.21608/mjmr.2022.221070
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Authors
Mohamed E. El-Refaey1; Yasser M. Ashour2; Lobna A. Abdelzaher3; Maher A. Shabaan1
1Department of Physiology, Faculty of Medicine, Al-Azhar University, Assuit, Egypt.
2Department of Physiology, Egyptian Russian University, Egypt.
3Department of Pharmacology, Faculty of Medicine, Assuit University, Egypt.
Abstract
Background: Osteoporosis affects women a lot especially older age after menopause. It may 
lead to bad back draws that may prone to considerable pathological conditions e.g. fracture 
and sever pain. Objective: This study aims to identify the effect of anti-oxidant and iron 
chelator on metabolic bone turnover in ovariectomized rats. Materials and Methods: The 
rats were divided into five groups, negative control, positive control, desferal treated, vitamin 
E treated and desferal + vitamin E treated groups. determination of serum estrogen, ferritin, 
ALP, TNF α and osteocalcin at the end of experiment. Also, morphology of bone in female 
rats were evaluated at the end of experiment. Results: The ovariectomy lead to decrease in 
serum estrogen level and increase serum level of ferritin, ALP, TNF α and osteocalcin. On the 
other hand usage of desferal and vitamin E lead to decrease serum level of ferritin, ALP, TNF 
α and osteocalcin. Histological picture of bone, our results showed that abnormal structure of 
bone of untreated group versus to improvement in histological picture of treated groups.
Conclusion: The female rats alleged to ovariectomy and suffered from osteoporosis will be 
showed improved in her bone by using desferal and vitamin E alone or in combination. 
. 
Keywords
Ovariectomy; Vitamin E; Desferal; Bone remodeling
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