Leptin Receptor Expression in Obesity-Associated Acanthosis Nigricans | ||||
| Minia Journal of Medical Research | ||||
| Volume 31, Issue 2, April 2020, Page 308-312 PDF (434.89 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2022.221080 | ||||
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| Authors | ||||
| Essam E. Mohammed1; Refaat R. Mohammed1; Ahmed A. Elhakeem2; Amira A. Riad3 | ||||
| 1Department of Dermatology , Andrology , STDS Al-Azhar university (Assiut), Egypt. | ||||
| 2Department of Pathology Al-Azhar university (Assiut), Egypt. | ||||
| 3Department of Dermatology ,Andrology And STDS At Dairout Hospital, Assiut, Egypt. | ||||
| Abstract | ||||
| Background: Obesity-associated acanthosis nigricans is the most common type of acanthosis nigricans. Aim of wok: To detect leptin receptor expression in the skin lesion affected by obesityassociated acanthosis nigricans. Patients and methods: Twenty patients suffering from obesityassociated acanthosis nigricans were included in this prospective study. Complete history taking, thorough general examination and calculation of body mass index were done for all patients. Leptin receptor expression was investigated in skin lesion and perilesional skin by immunohistochemistry. Results: The mean age of the patients was 19.5 ±7.561 years and the mean duration of the disease was 8.6 ± 6.44 years. 14 patients were females and 6 patients were males. The mean BMI of the examined patients was (31.5 ± 4.4). The expression of leptin receptors was significantly higher in skin lesions than perilesional skin of the patients. Conclusion: leptin receptor expression was significantly higher in skin lesions affected by obesityassociated AN. | ||||
| Keywords | ||||
| Obesity; Acanthosis nigricans; leptin. | ||||
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