Comparison between central venous and arterial gases level versus lactate clearance as an indicator of initial resuscitation in septic patients in intensive care unit
Youseif, I., Mohammed, A., Farghly, R. (2020). Comparison between central venous and arterial gases level versus lactate clearance as an indicator of initial resuscitation in septic patients in intensive care unit. EKB Journal Management System, 31(2), 335-339. doi: 10.21608/mjmr.2022.221095
Ibrahim A. Youseif; Ahmad H. Mohammed; Rehab M. Farghly. "Comparison between central venous and arterial gases level versus lactate clearance as an indicator of initial resuscitation in septic patients in intensive care unit". EKB Journal Management System, 31, 2, 2020, 335-339. doi: 10.21608/mjmr.2022.221095
Youseif, I., Mohammed, A., Farghly, R. (2020). 'Comparison between central venous and arterial gases level versus lactate clearance as an indicator of initial resuscitation in septic patients in intensive care unit', EKB Journal Management System, 31(2), pp. 335-339. doi: 10.21608/mjmr.2022.221095
Youseif, I., Mohammed, A., Farghly, R. Comparison between central venous and arterial gases level versus lactate clearance as an indicator of initial resuscitation in septic patients in intensive care unit. EKB Journal Management System, 2020; 31(2): 335-339. doi: 10.21608/mjmr.2022.221095

Comparison between central venous and arterial gases level versus lactate clearance as an indicator of initial resuscitation in septic patients in intensive care unit

Minia Journal of Medical Research
Volume 31, Issue 2, April 2020, Page 335-339  XML PDF (362.05 K)
Document Type: Original Article
DOI: 10.21608/mjmr.2022.221095
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Authors
Ibrahim A. Youseif; Ahmad H. Mohammed; Rehab M. Farghly
Department of Anesthesia,intensive care and pain management; Minia Faculty of Medicine; Egypt
Abstract
Objective: Aim of this study: was to compare the central venoarterial carbon dioxide 
difference/arterial-central venous oxygen difference (P(va)CO2/C(a-v)O2) ratio versus 
lactate clearance as an indicator to evaluate the steps of initial resuscitation in septic patients. 
Patients and methods: Our study was conducted in the ICU,Minia University Hospital. 
Eighty patients with severe sepsis or septic shock. Results: There was improvement in CVP, 
MAP, or Scvo2 at T8 after early resuscitation with no significant differences between group1 
and group 2 and inside each group. There were no significant difference in P(v-a)CO2/C(av)O2 ratio at T0 and at T8 at group 1. However there was higher lactate level at T0 and 
exhibited significantly lower at T8 in group 2. Conclusion: Further clinical trials are needed 
to conclusively establish lactate clearance as a resuscitation endpoint and an outcome measure 
to be targeted during the most proximal phases of severe sepsis and septic shock.

Keywords
CVP; MAP; Scvo2
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