Estimation of the Level of Interlukien-33 and Interferon–γ in Lesional and Nonlesional Tissues of Patients with Viral Warts and in Healthy Controls
El-Rifaie, A., Rashed, L., AbdAllah, A., Taghyan, M. (2020). Estimation of the Level of Interlukien-33 and Interferon–γ in Lesional and Nonlesional Tissues of Patients with Viral Warts and in Healthy Controls. EKB Journal Management System, 31(2), 355-362. doi: 10.21608/mjmr.2022.221098
Abd El-Aziz El-Rifaie; Laila A. Rashed; Ahlam H. AbdAllah; Maha I. Taghyan. "Estimation of the Level of Interlukien-33 and Interferon–γ in Lesional and Nonlesional Tissues of Patients with Viral Warts and in Healthy Controls". EKB Journal Management System, 31, 2, 2020, 355-362. doi: 10.21608/mjmr.2022.221098
El-Rifaie, A., Rashed, L., AbdAllah, A., Taghyan, M. (2020). 'Estimation of the Level of Interlukien-33 and Interferon–γ in Lesional and Nonlesional Tissues of Patients with Viral Warts and in Healthy Controls', EKB Journal Management System, 31(2), pp. 355-362. doi: 10.21608/mjmr.2022.221098
El-Rifaie, A., Rashed, L., AbdAllah, A., Taghyan, M. Estimation of the Level of Interlukien-33 and Interferon–γ in Lesional and Nonlesional Tissues of Patients with Viral Warts and in Healthy Controls. EKB Journal Management System, 2020; 31(2): 355-362. doi: 10.21608/mjmr.2022.221098

Estimation of the Level of Interlukien-33 and Interferon–γ in Lesional and Nonlesional Tissues of Patients with Viral Warts and in Healthy Controls

Minia Journal of Medical Research
Volume 31, Issue 2, April 2020, Page 355-362  XML PDF (554.88 K)
Document Type: Original Article
DOI: 10.21608/mjmr.2022.221098
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Authors
Abd El-Aziz El-Rifaie; Laila A. Rashed; Ahlam H. AbdAllah; Maha I. Taghyan
Department of Dermatology, El-Minia Fcaulty of Medicine
Abstract
Background: Viral warts are benign skin growths that are caused by Human Papilloma Virus 
(HPV). There are many types of warts either genital or non-genital. Interlukien-33 (IL-33) is a 
member of IL-1 family. It acts as alarmin molecule that provides protective antiviral immunity 
and plays an important role in many diseases. Interferon- γ (IFN-γ) has a well-known antiviral 
role and improves the expression of IL-33 in human keratinocytes in various diseases. Aim of 
this work: Estimation of the level of IL-33 and IFN-γ in lesional and non-lesional tissues of 
patients with viral warts and in healthy controls and evaluate their role in the pathogenesis of viral 
warts. Subjects and Methods: We did our study on two groups; 25 patients with viral warts and 
25 matching relatively healthy controls. We used enzyme linked immunosorbent assay (ELISA) 
kits to measure the levels of IL-33 and IFN-γ in 4mm diameter skin biopsies from the lesion 
itself, the non-lesional skin of the same patients and from skin of healthy controls to compare 
between the results. Results: The levels of IL-33 and IFN-γ in lesional and non-lesional tissues of 
viral warts were significantly higher than in healthy controls. Conclusion: Our presenting study 
is suggesting that IL-33 and IFN-γ may play a role in the pathogenesis of viral warts.

Keywords
Enzyme-linked immunosorbent assay; Interferon- γ; Interlukien-33; Viral warts
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