Ameliorative effects of bradykinin potentiating factor, butylated hydroxy toluene and oltipraz on biochemical and histological structure of lymphoid organs in aflatoxicated female rats | ||||
| Assiut University Journal of Multidisciplinary Scientific Research | ||||
| Volume 49, Issue 2, December 2020, Page 26-41 PDF (1.01 MB) | ||||
| Document Type: Novel Research Articles | ||||
| DOI: 10.21608/aunj.2020.221172 | ||||
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| Abstract | ||||
| Aflatoxins (AFs) are chemically secondary metabolites produced by Aspergillus, Penicillium and Fusarium genera. It has adverse effects on humans and animals health due to inhibition of macromolecule synthesis. The current research investigate the pathological and biochemical changes in lymph follicles of female rats exposed to aflatoxin B1 (AFB1) for one month and the efficacy of isolated bradykinin potentiating factor (BPF) from cobra snake venom, butylated hydroxy toluene (BHT) and oltipraz (OPZ) to ameliorate those changes. Aflatoxicosis cause significant increase of lipid peroxidation (LPO) and nitric oxide (NO) in addition to significant decrease in the level of total thiols, glutathione (GSH) and the activities of glutathione peroxidase (GPx) and glutathione S-transferase (GST). Moreover, AFB1 caused Sa | ||||
| Keywords | ||||
| lymph follicles; aflatoxin B1; oxidative stress; butylated hydroxy toluene; bradykinin potentiating factor; oltipraz | ||||
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