Simple and convenient synthesis of the bladder cancer biomarker: Nicotinuric acid | ||||
| Assiut University Journal of Multidisciplinary Scientific Research | ||||
| Volume 47, Issue 2, December 2018, Page 100-106 PDF (447.5 K) | ||||
| Document Type: Novel Research Articles | ||||
| DOI: 10.21608/aunj.2018.221259 | ||||
 View on SCiNiTO | ||||
| Abstract | ||||
| The present work describes a simple and convenient synthesis of nicotinoylglycine (nicotinuric acid) and some other aroylglycines such as substituted pyrazoloylglycines starting from their corresponding carboxylic acids. These acids were converted via two different methodologies, into their corresponding acid azides which were reacted with glycine in alkaline medium to give the target aroylglycines in very good yield. The use of the prepared nicotinuric acid as biomarker for early detection of bladder cancer will be the subject of a next publication. | ||||
| Keywords | ||||
| bladder cancer; biomarkers; aroylglycines; nicotinoylglycine; pyrazol-4-oylglycine | ||||
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