Pentraxin-3: A Novel Specific Biomarker for Inflammatory Bowel Disease Diagnosis | ||||
| Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology | ||||
| Article 14, Volume 14, Issue 1, June 2022, Page 153-163 PDF (734.06 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/eajbsc.2022.221330 | ||||
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| Authors | ||||
Ibrahim O. Ibrahim1; Inas M. Masoud 2; Ù‹Wessam F. El-Hadidy 3
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| 1Faculty of pharmacy, Pharos University in Alexandria, Egypt | ||||
| 2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pharos University in Alexandria, Egypt. | ||||
| 3Department of Pharmacology & Experimental Therapeutics, Medical Research Institute, Alexandria University, Egypt. | ||||
| Abstract | ||||
| Background and aim: Inflammatory bowel disease (IBD); includes Crohn's disease (CD) and ulcerative colitis (UC) is a chronic condition. Endoscopy is the most effective method in the diagnosis of IBD, although it is an invasive, uncomfortable procedure. Pentraxin-3 (PTX-3) is a primary local inflammatory biomarker. This study aims to prove that PTX-3 shows sensitivity and specificity in the diagnosis of IBD as a non-invasive biomarker. Subjects and methods: Thirty-six (45 ± 15years) subjects, were divided into Group I (control): 12 healthy volunteers, group II: 12 CD patients and group III: 12 UC patients. Serum levels of PTX-3, antinuclear antibody (ANA) and C-reactive protein (CRP)as well as fecal calprotectin level were assessed at the start of the study and at the end of 8 weeks mesalazine treatment. Results: Results revealed a significant elevation of both calprotectin and PTX-3 levels in either CD or UC- patients in comparison to the control, with no significant difference between them regarding CRP and ANA levels. After mesalazine therapy, serum PTX-3 level was significantly decreased in both UC and CD patients, while no significant change has been detected in other studied parameters. Conclusion: PTX-3 can be used as a sensitive, specific, non-invasive inflammatory biomarker for diagnosis and follow-up of IBDs. | ||||
| Keywords | ||||
| Inflammatory Bowel Disease (IBD); Pentraxin-3 | ||||
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