Protective activity of phalaris canariensis against methotrexate-induced nephrotoxicity via BCL2 pathway
Rofaeil, R., Ali, D., Gad ElMolla, S., Attya, M. (2020). Protective activity of phalaris canariensis against methotrexate-induced nephrotoxicity via BCL2 pathway. EKB Journal Management System, 31(1), 1-11. doi: 10.21608/mjmr.2022.221382
Remon R. Rofaeil; Doaa M. Elroby Ali; Sayed . Gad ElMolla S Gad ElMolla; Mina E. Attya. "Protective activity of phalaris canariensis against methotrexate-induced nephrotoxicity via BCL2 pathway". EKB Journal Management System, 31, 1, 2020, 1-11. doi: 10.21608/mjmr.2022.221382
Rofaeil, R., Ali, D., Gad ElMolla, S., Attya, M. (2020). 'Protective activity of phalaris canariensis against methotrexate-induced nephrotoxicity via BCL2 pathway', EKB Journal Management System, 31(1), pp. 1-11. doi: 10.21608/mjmr.2022.221382
Rofaeil, R., Ali, D., Gad ElMolla, S., Attya, M. Protective activity of phalaris canariensis against methotrexate-induced nephrotoxicity via BCL2 pathway. EKB Journal Management System, 2020; 31(1): 1-11. doi: 10.21608/mjmr.2022.221382

Protective activity of phalaris canariensis against methotrexate-induced nephrotoxicity via BCL2 pathway

Minia Journal of Medical Research
Volume 31, Issue 1, January 2020, Page 1-11  XML PDF (979.59 K)
Document Type: Original Article
DOI: 10.21608/mjmr.2022.221382
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Authors
Remon R. Rofaeil1; Doaa M. Elroby Ali2; Sayed . Gad ElMolla S Gad ElMolla3; Mina E. Attya4
1Department of Pharmacology, Faculty of Medicine, Minia University, Egypt. Department of Pharmacology and toxicology, Faculty of Pharmacy, Deraya University, Egypt.
2Department of Biochemistry, Faculty of pharmacy, Deraya University, Egypt.
3Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, Egypt
4Department of Pathology, Faculty of Medicine, Minia University, Egypt.
Abstract
This study aimed to evaluate the protective effects of the ethanolic extract obtained from the seeds of 
phalaris canariensis, against nephro-toxicity induced by methotrexate (MTX). Toxicity was induced 
by a single dose of MTX (20 mg/kg) and ethanolic extract administered in three different doses (100, 
200 and 400 mg/kg) daily for 15 days. Urea and creatinine were measured in serum. In addition, 
malondialdehyde (MDA) and total nitrites, were measured in kidney tissues. At the same time, 
expression of kidney injury molecule-1 (KIM-1) and expression of BCL2 in kidney were measured. 
The ethanolic extract showed dose-dependent reduction in urea, creatinine, renal MDA, renal total 
nitrites and expression of KIM-1, which were increased with MTX administration, however, the 
extract dose-dependently, increased BCL2 expression that was reduced with MTX administration. in 
conclusion, this study suggests that the seed extracts from P. canariensis exhibit protective potentials 
against MTX-induced nephro-toxicity and can be considered a potential therapeutic agent in 
prevention of MTX-induced toxicity.

Keywords
Methotrexate; Phalaris canariensis; BCL2; nephrotoxicity.Protective activity of Phalaris canariensis against methotrexate-induced nephrotoxicity via BCL2 pathway. 
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