Organosilicon Surfactants as Antitumor Agents | ||||
| Egyptian Journal of Chemistry | ||||
| Article 55, Volume 65, Issue 10, October 2022, Page 577-584 PDF (632.85 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2022.114183.5223 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
sahar ahmed; Dina Ismail   ; Dalia Mohamed
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| Petrochemicals Department, Egyptian Petroleum Research Institute, Cairo, 11727, Egypt. | ||||
| Abstract | ||||
| Organosilicon surfactants draw scientific attention due to their significant biological action as they offer the real possibility to improve their pharmacological properties because of easier penetration through lipophilic barriers inside the body. Synthesis, structure and spectroscopic characterization of cobalt (II), copper (II) and zinc (II) coordination compounds with N-dodecyl-N-trimethyl silane ammonium iodide are presented in this research. N-dodecyl-N-trimethyl silane ammonium iodide and its complexes with cobalt, copper and zinc chlorides were characterized structurally using Ultraviolet-Visible and Fourier Transform Infra-red spectra. Surface parameters of the prepared surfactants were investigated including, critical micelle concentration, maximum surface excess, minimum surface area, effectiveness, and efficiency. Free energy of micellization and adsorption were also calculated. The cytotoxic activity of various metallomicelle surfactants was tested against five lines of human tumor cells [ HEPG2 (liver), MCF-7 (breast), HCT-116 (colon), HEP2 (larynx), and HFB4 (normal)]. The results showed that zinc (II) and cobalt (II) complexes have substantial surface and cytotoxic activity whereas copper (II) complex showed less surface and cytotoxic activity. | ||||
| Keywords | ||||
| Cytotoxic Activity; Silicon Surfactant; Metallomicelles and Surface Parameters | ||||
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