Intranasal injection of Botulinum toxin type A in treatment of allergic rhinitis. | ||||
Minia Journal of Medical Research | ||||
Volume 31, Issue 1, January 2020, Page 323-329 PDF (502.86 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/mjmr.2022.221544 | ||||
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Authors | ||||
Balegh , H. Abdel-Hak; Osama G.; Alaa N. Alsaied | ||||
Department of Otolaryngology, fucalty of Medicine, Minya university, Egypt . | ||||
Abstract | ||||
Objectives: We tested the effects of BTA injections in septum ,middle and inferior turbinates, on patients who had AR for a minimum of three years and had been treated unsuccessfully with conventional medications. Method: The study was an interventional case-control single-blind randomized clinical trial . 20 male and female AR patients who were referred to the hospital of Minya university ,in 2019; aged 15-52 years were selected on the basis of inclusion and exclusion criteria. The subjects were randomly assigned to the intervention (n=10) or control group (n=10). The intervention group received BTA (45 IU/ml; medytox), by injection intranasally in septum , middle and inferior turbinates. The control group received normal saline. The groups were evaluated by the same examiner. post-tests (1,4, and 12 weeks) were performed according to the authors’ pre-designed checklist, the validity and reliability of which was previously established. The symptoms scored from none (0) to severe (10) at the test points. The statistical analysis was conducted with SPSS-19, with a significance level of 0.05. Results: Based on ANOVA, there was a significant difference (P<0.05) in symptomatic relief between the intervention and control groups. No marked adverse effects were observed during the study. Discussion: An intranasal injection of BTA, , may alleviate AR symptoms with no significant adverse effects. | ||||
Keywords | ||||
Botulinum Toxin type A(BTA); allergic rhinitis (AR) | ||||
Supplementary Files
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