Therapeutic Efficacy and Tolerability of 30% Versus 70% Concentrations of Topical Trichloroacetic Acid in Patients with Xanthelasma Palpebrarum: A Randomized Clinical Trial | ||||
| Minia Journal of Medical Research | ||||
| Article 14, Volume 30, Issue 4, October 2019, Page 86-92 PDF (239.15 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2022.221692 | ||||
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| Author | ||||
| Mona A. Nassief | ||||
| Department of Ophthalmology, Tanta University, Egypt | ||||
| Abstract | ||||
| Background: Xanthelasma palpebrarum (XP) is the most common cutaneous xanthoma. It is a benign lesion that appears as yellowish plaque near the inner canthus of the eyelid. There is still paucity of strong evidence for the single best effective treatment of XP. Objective: The aim of this study was to assess the clinical efficacy and tolerability of once application of two concentrations of topical trichloroacetic acid (TCA) (30% versus 70%) in treatment of patients with XP. Methods: This randomized clinical trial was conducted on patients presenting to Occuloplastic Clinic at Tanta University Eye Hospital. Patients with Soft and semisolid xanthelasma lesion at upper or lower eyelids were included. Forty patients were randomly distributed into 2 groups: Group 1 treated by once application of 30% TCA and Group 2 treated by once application of 70% TCA. Results: There was a statistically significant (p<0.001) improvement in group 2 compared to group 1. Excellent results where the skin of the lesion returned normal as the rest of the surrounding skin were significantly higher in group 2 (94.1%) than group 1 (14.7%). Group 2 showed absence of significant (p>0.05) association between the clinical outcome and the number, type, or size of the lesion. There was a statistically significant (p<0.001) increase in lid erythema in group 2 compared to group 1 (45.0% versus 0.0%, respectively). Conclusion: A single session peeling with TCA 70% was highly effective than TCA 30% in the treatment of xanthelasma palpebrarum patients whatever the number, type, or size of lesion. The only significantly reported side effect was lid erythema. | ||||
| Keywords | ||||
| xanthelasma palpebrarum; trichloroacetic acid; chemical cauterization; randomized clinical trial | ||||
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