Possible Role of Regulatory T Cells (CD4+and CD25+) in Pathogenesis of Childhood Immune Mediated Thrombocytopenia | ||||
| Minia Journal of Medical Research | ||||
| Article 24, Volume 30, Issue 4, October 2019, Page 152-154 PDF (498.28 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2022.221702 | ||||
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| Authors | ||||
| Sally F. Matta; Khaled M. Salah; Emad A. Abd El-Naeem | ||||
| Department of Clinical Pathology, Faculty of Medicine, Minia University | ||||
| Abstract | ||||
| Immune mediated thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by production of auto-antibodies against platelet antigens. It is obvious that regulatory T cells (Tregs) have a major role in controlling immune homeostasis and preventing autoimmunity. To investigate the frequency of Tregs, twenty newly diagnosed, twenty chronic ITP children and twenty age and sex matched healthy controls were recruited. The peripheral blood mononuclear cells were isolated and the proportion of Tregs was defined by flow cytometry method. Results showed that the frequency of Tregs significantly decreased in newly diagnosed and chronic ITP patients compared to those in healthy controls. It could be concluded that Tregs might play a role in the pathogenesis of ITP. | ||||
| Keywords | ||||
| Immune mediated thrombocytopenia; autoimmune bleeding | ||||
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